Dentistry Journal

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Dear Colleagues,

Orthodontic and dentofacial orthopaedic treatment is undergoing a profound transformation. Advances in biological understanding, digital technologies, and appliance design have increasingly enabled a shift from standardised protocols toward personalised, biologically driven treatment concepts. Rather than focusing solely on treatment duration, contemporary orthodontics aims to optimise efficiency, effectiveness, and biological compatibility while minimising side effects and enhancing long-term stability.

This Special Issue, “Personalised and Biologically Driven Orthodontics and Dentofacial Orthopaedics”, will bring together current research and emerging concepts that tailor orthodontic and orthopaedic interventions to the individual patient. These approaches integrate biological timing, growth potential, tissue response, biomechanics, and digital workflows to refine treatment planning and execution.

Innovative strategies include individualised CAD/CAM-designed appliances, multipurpose orthodontic and orthopaedic devices, optimised skeletal anchorage concepts, and protocols that exploit or extend growth and remodelling windows. Accelerated orthodontic techniques are often considered within this broader paradigm as being embedded in a framework prioritising biological plausibility, patient safety, and clinical predictability.

This Special Issue will provide a platform for basic, translational, and clinical research, as well as high-quality reviews, highlighting biologically informed and personalised strategies for future-oriented orthodontic care.

Prof. Dr. Kathrin Becker
Guest Editor

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Keywords

personalised orthodontics
biologically driven orthodontics
individualised treatment planning
treatment efficiency
clinical effectiveness
patient-centred orthodontics
dentofacial orthopaedics
growth modulation
digital orthodontics
artificial intelligence in orthodontics
virtual treatment planning
timing
accelerated orthodontics (surgical and non-surgical)
risk–benefit assessment

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10 pages, 1078 KB

Open AccessSystematic Review

Modulation of Orthodontic Tooth Movement by Statins: A Systematic Review of Animal Studies

by Roberta Crispino, Francesca Zara, Massimiliano Vella, Lara Colaianni, Cinzia Maspero, Marco Serafin and Alberto Caprioglio

Dent. J. 2026, 14(6), 331; https://doi.org/10.3390/dj14060331 - 1 Jun 2026

Viewed by 208

Abstract

Objective: This systematic review aims to evaluate the effects of statin administration on orthodontic tooth movement (OTM) and post-treatment relapse in animal models. Materials and Methods: Following PRISMA guidelines and PROSPERO registration (CRD42025612449), a comprehensive literature search was performed in PubMed, Scopus, and the Cochrane Library up to December 2025. The search strategy included studies on animal models treated with any form of statin during OTM or relapse phases. Eligibility criteria were defined using the PICOS framework. Data extraction focused on study characteristics, statin administration protocol, orthodontic mechanics, and both histological and molecular markers of bone remodeling. Risk of bias was assessed with SYRCLE’s tool. Results: Seven in vivo animal studies met the inclusion criteria. Simvastatin and atorvastatin were investigated using heterogeneous experimental models, doses, administration routes, orthodontic mechanics, and follow-up periods. Findings suggested that statins may reduce active orthodontic tooth movement or post-orthodontic relapse in some experimental settings, but effects were not uniform across studies. Histological outcomes, when reported, generally indicated reduced osteoclast activity, fewer resorption lacunae, or more mature alveolar bone in statin-treated animals. Molecular outcomes were less consistently reported and mainly involved OPG/RANKL-related pathways, Runx2, or ALP expression. Conclusions: Statins, particularly simvastatin, show potential to modulate orthodontic tooth movement and reduce relapse by influencing bone metabolism. Nevertheless, due to methodological variability and the exclusive reliance on animal models, these results cannot yet be translated into clinical recommendations. Current preclinical evidence suggests that statins may modulate bone remodeling during active orthodontic tooth movement and after appliance removal. However, the evidence remains limited to a small number of heterogeneous animal studies with incomplete reporting of key outcomes and several unclear risk-of-bias domains. Clinical translation is premature, and more standardized preclinical studies are required before human investigations can be justified. Full article

(This article belongs to the Special Issue Personalised and Biologically Driven Orthodontics and Dentofacial Orthopaedics)

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