Recreational Drugs, Smoking, and Their Impact on Oral Health

A special issue of Dentistry Journal (ISSN 2304-6767).

Deadline for manuscript submissions: 30 November 2026 | Viewed by 3092

Special Issue Editors


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Guest Editor

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Guest Editor
Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, NV 89106, USA
Interests: oral; dental medicine

Special Issue Information

Dear Colleague,

The increasing use of recreational drugs and tobacco presents significant challenges to both general and oral health. These substances have well-documented effects on the oral cavity, contributing to a range of complications that affect teeth, the periodontium, soft tissues, and overall oral function. Despite this, gaps remain in our understanding of the precise mechanisms, clinical implications, and effective management of the effects of smoking and recreational drugs on the oral cavity.

This Special Issue aims to provide a comprehensive exploration of the short- and long-term effects of recreational drug use and smoking on oral health. We therefore welcome the submission of the following:

  • Original research articles that present novel findings regarding the impact of recreational drugs and smoking (including vaping and e-cigarettes) on oral structures, salivary composition, and disease progression.
  • Systematic reviews that critically assess existing literature on drug-related oral health complications.
  • Clinical case reports that offer unique insights into diagnosis, management, and treatment challenges.
  • Perspective pieces that propose innovative viewpoints and future directions in research, prevention, and policy-making.

The scope of this Special Issue includes the following topics: 

  • The effects of recreational drugs and smoking on oral structures, including enamel, dentin, the periodontium, and mucosa.
  • The influence of substance use on salivary gland function, xerostomia, and the increased risk of caries.
  • Drug-induced oral health behaviors (e.g., bruxism, poor hygiene, dietary changes) and their role in disease exacerbation.
  • The impact of vaping and e-cigarettes on periodontal and oral mucosal health.
  • Challenges in dental management and treatment planning for patients with a history of substance use.
  • Interdisciplinary approaches that integrate dentistry with addiction medicine and public health efforts.
  • Preventive strategies, educational initiatives, and policy recommendations for reducing the oral health risks associated with substance use.

By compiling research from multiple disciplines, this Special Issue aims to foster collaboration among dental professionals, researchers, public health experts, and addiction specialists. We invite you to contribute to this vital discussion, advancing both clinical care and public health interventions for individuals affected by substance use.

Submission Guidelines:

Manuscripts should adhere to the journal's submission guidelines and formatting requirements. All submissions will undergo a rigorous peer-review process.

For inquiries, please contact the Guest Editor(s) or the Managing Editor Ms. Adele Min (adele.min@mdpi.com).

We look forward to receiving your contributions to this critical field of research.

Prof. Dr. Neamat Hassan Abubakr
Dr. John Colombo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral health
  • recreational drugs
  • smoking
  • periodontal
  • oral mucosal health
  • oral function
  • oral structures

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Published Papers (2 papers)

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Research

20 pages, 2642 KB  
Article
Influence of E-Liquids and Oral Commensal Bacteria on the Growth of Porphyromonas gingivalis Planktonically and in Biofilms
by Sabeen Safi, Danna Berro, Juliette Amram, Daniel Burden, Dominic Palazzolo and Giancarlo A. Cuadra
Dent. J. 2026, 14(3), 172; https://doi.org/10.3390/dj14030172 - 17 Mar 2026
Viewed by 1074
Abstract
Background: The increasing use of electronic cigarettes (ECIGs), especially among youth, has raised concerns about the impact of vaping on oral health. While ECIGs are often marketed as a safer alternative, the existing literature suggests that their use may have detrimental effects [...] Read more.
Background: The increasing use of electronic cigarettes (ECIGs), especially among youth, has raised concerns about the impact of vaping on oral health. While ECIGs are often marketed as a safer alternative, the existing literature suggests that their use may have detrimental effects on the pulmonary and cardiovascular systems. The oral cavity is the first point of contact for ECIG aerosol, and new reports link vaping to the onset of periodontal disease. It is critical to understand the potential effects of vaping on the oral microbiome, which affects systemic health. This study investigates how flavored E-liquids and commensal bacteria influence the growth of Porphyromonas gingivalis, a periodontal pathobiont, under planktonic and biofilm conditions. Methods: P. gingivalis was grown planktonically in the presence of the supernatants of four streptococcal species (Streptococcus gordonii, Streptococcus intermedius, Streptococcus mitis, and Streptococcus oralis) and flavored E-liquids (tobacco, menthol, cinnamon, strawberry, and blueberry) under anaerobic conditions. Multispecies biofilms, including all the species mentioned above and Fusobacterium nucleatum, were also grown anaerobically and quantified by crystal violet assays, qPCR, and CFU counts. Results: Although E-liquids inhibit P. gingivalis growth under planktonic conditions, the presence of commensal supernatants partially mitigates this effect. However, P. gingivalis growth in multispecies biofilms is increased by E-liquid treatments. Conclusions: This study highlights the enhanced growth of P. gingivalis as part of an oral microbial community in the presence of E-liquids. These results suggest that E-liquid-induced alterations in multispecies biofilms may contribute to the observed dysbiosis in vapers and the associated risk of oral diseases. Full article
(This article belongs to the Special Issue Recreational Drugs, Smoking, and Their Impact on Oral Health)
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14 pages, 1895 KB  
Article
MicroRNA Signatures in Dental Pulp Stem Cells Following Nicotine Exposure
by David Vang, Leyla Tahrani Hardin, Nabil Abid, Der Thor and Nan Xiao
Dent. J. 2025, 13(8), 338; https://doi.org/10.3390/dj13080338 - 23 Jul 2025
Cited by 1 | Viewed by 1323
Abstract
Background and Objectives: Nicotine is the most well-studied toxic substance in cigarette smoke and e-cigarette vape. However, smoke and vape are composed of other components that have a negative impact on health. The objective of this study is to investigate whether nicotine has [...] Read more.
Background and Objectives: Nicotine is the most well-studied toxic substance in cigarette smoke and e-cigarette vape. However, smoke and vape are composed of other components that have a negative impact on health. The objective of this study is to investigate whether nicotine has a distinctive impact on molecular mechanisms in stem cells. Methods: The cellular impact of nicotine on the regenerative capacity of human dental pulp stem cells (DPSCs) and the microRNA (miRNA) profile was examined. Bioinformatic analysis was performed to identify miRNA-regulated cellular pathways associated with nicotine exposure. These pathways were then compared to those induced by cigarette smoke condensate (CSC). Results: Prolonged exposure to nicotine significantly impaired the regeneration of DPSCs and changed the expression of miRNAs. Nicotine upregulated the expression of hsa-miR-7977, hsa-miR-3178, and hsa-miR-10400-5p compared to vehicle control. Interestingly, nicotine did not change the expression of hsa-miR-29b-3p, hsa-miR-199b-5p, hsa-miR-26b-5p, or hsa-miR-26a-5p compared to the control. However, the expressions of these miRNAs were significantly altered when compared to CSC treatment. Further analysis revealed that nicotine was distinctively associated with certain miRNA-targeted pathways including apoptosis, ErbB, MAPK signaling, PI3K-Akt, TGF-b signaling, and Wnt signaling. Conclusions: Our work provides evidence on the distinctive miRNA signature induced by nicotine. The information will be important for identifying the unique molecular pathways downstream of nicotine from smoking and vaping in different individuals, providing a new direction for personalized disease prevention, prognosis, and treatment. Full article
(This article belongs to the Special Issue Recreational Drugs, Smoking, and Their Impact on Oral Health)
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