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Dentistry Journal
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Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional...
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Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional Treatment in Periodontitis Patients - A Special Challenge?

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Oral Hygiene, Periodontology and Peri-implant Diseases".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 9604

Special Issue Editors

Dr. Philipp Sahrmann

E-Mail Website
Guest Editor
Department of Periodontology, Endodontology and Cariology, University Centre for Dental Medicine, University of Basel, 4058 Basel, Switzerland
Interests: anti-inflammatory therapies in periodontitis and peri-implantitis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrea Pilloni

E-Mail Website
Guest Editor
Department of Oral and Maxillo-Facial Sciences, “Sapienza” University of Rome, 00185 Rome, Italy
Interests: periodontal regeneration; periodontal wound healing; periodontal health

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue, titled “Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional Treatment in Periodontitis Patients - A Special Challenge?”.

This Special Issue aims to provide a platform for networking and communication between Dentistry Journal and scholars focused on the study of inflammation prophylaxis, aesthetic and functional treatment in periodontitis. All papers will be published as open access articles upon completing peer review.

Please feel free to contact the Managing Editor Ms. Adele Min (adele.min@mdpi.com) with any questions.

We look forward to receiving your contributions.

Dr. Philipp Sahrmann
Prof. Dr. Andrea Pilloni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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9 pages, 1515 KiB  
Article
Synergistic Effect of Metronidazole and Chlorhexidine against Porphyromonas gingivalis Growth: An In Vitro Study
by Claudia Lorenzi, Fabrizio Lio, Vincenzo Mazzetti, Paolo Carosi, Stefano Lamelza, Enrico Salvatore Pistoia, Francesca Pica and Roberta Gaziano
Dent. J. 2024, 12(10), 307; https://doi.org/10.3390/dj12100307 - 27 Sep 2024
Cited by 2 | Viewed by 1587
Abstract
Aim: To evaluate the potential synergistic activity of metronidazole (MTZ) and chlorhexidine (CHX) against Porphyromonas. gingivalis (P. gingivalis) growth. Methods: Antimicrobial susceptibility tests of P. gingivalis to MTZ and CHX were performed on in vitro serial 2-fold dilutions of MTZ (from 1 mg/mL to [...] Read more.
Aim: To evaluate the potential synergistic activity of metronidazole (MTZ) and chlorhexidine (CHX) against Porphyromonas. gingivalis (P. gingivalis) growth. Methods: Antimicrobial susceptibility tests of P. gingivalis to MTZ and CHX were performed on in vitro serial 2-fold dilutions of MTZ (from 1 mg/mL to 0.015 mg/mL) and CHX (from 1 mg/mL to 0.03 mg/mL) in thioglycollate medium broth in a 96-well plate. The turbidity of each sample was analyzed by absorbance spectrophotometry at 450 nm wavelengths by using an enzyme-linked immunosorbent assay (ELISA) reader. The MIC50 (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) were assessed. To investigate the potential synergism between MTZ and CHX, bacterial cells were treated with MTZ or CHX, as described above, either alone or in combination. Results: The MIC50 of MTZ was 0.03 mg/mL while that of CHX ranged from 0.12 to 0.06 mg/mL. MTZ and CHX exerted a significant inhibitory effect on P. gingivalis growth in a dose-dependent manner. MTZ at a low and ineffective concentration of 0.015 mg/mL, associated with a suboptimal concentration of CHX (0.03 mg/mL), exhibited a significant synergistic inhibitory effect on bacterial growth (50% inhibition vs. control) (p < 0.001), and the effect was more remarkable with 0.06 mg/mL CHX (75% inhibition vs. control). Conclusions: CHX and MTZ showed a significant synergistic effect against P. gingivalis growth. A non-effective concentration of MTZ (0.015 mg/mL) combined with suboptimal concentrations of CHX (0.03 mg/mL and 0.06 mg/mL) were related to a 50% growth in the inhibition and 99.99% death of P. gingivalis, respectively. The applicability of the clinical use of these concentrations should be tested in randomized controlled trials. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional Treatment in Periodontitis Patients - A Special Challenge?)
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10 pages, 884 KiB  
Article
A Novel Piezoelectric-Assisted Non-Surgical Periodontal Treatment: A Prospective Case Series
by Roberto Rotundo, Lorenzo Marini, Mauro Carere, Cinzia Trezza, Giovanni Marras, Michele Nieri and Andrea Pilloni
Dent. J. 2023, 11(7), 178; https://doi.org/10.3390/dj11070178 - 20 Jul 2023
Cited by 1 | Viewed by 2120
Abstract
The purpose of this study was to evaluate the clinical efficacy of a non-surgical periodontal treatment using a piezoelectric power-driven device with a novel insert. Plaque index (PlI), bleeding on probing (BoP), probing depth (PD), recession depth (Rec) and clinical attachment level (CAL) [...] Read more.
The purpose of this study was to evaluate the clinical efficacy of a non-surgical periodontal treatment using a piezoelectric power-driven device with a novel insert. Plaque index (PlI), bleeding on probing (BoP), probing depth (PD), recession depth (Rec) and clinical attachment level (CAL) were assessed at 6 weeks, 3 months and 6 months. Furthermore, tooth mobility and furcation involvement were recorded and chewing discomfort and dental hypersensitivity were evaluated. Eighteen stage I to IV periodontitis patients providing 437 teeth and 2622 sites in total were analyzed. At six weeks, CAL gain (0.4; p < 0.0001), PD reduction (0.4; p < 0.0001) and Rec increase (0.1; p = 0.0029) were statistically significant. Similarly, the mean number of sites with PD > 4 mm and absence of BoP significantly decreased between baseline and 6 weeks (−12.7; p < 0.0001). At this time point, the patient’s chewing discomfort was also significantly diminished (1.4; p = 0.0172). Conversely, no statistically significant changes were observed between 6 weeks and 3 months and between 3 months and 6 months for any of the clinical variables evaluated. In conclusion, within the limitation of this study, mechanical piezo-assisted non-surgical periodontal treatment in conjunction with an innovative tip resulted significantly efficacious to reduce pathological periodontal pockets, to gain clinical attachment and to reduce gingival inflammation. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional Treatment in Periodontitis Patients - A Special Challenge?)
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Review

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17 pages, 889 KiB  
Review
The Influence of Orthodontic Treatment on Periodontal Health between Challenge and Synergy: A Narrative Review
by Ionut Luchian, Zenovia Surlari, Ancuta Goriuc, Nicoleta Ioanid, Irina Zetu, Oana Butnaru, Monica-Mihaela Scutariu, Monica Tatarciuc and Dana-Gabriela Budala
Dent. J. 2024, 12(4), 112; https://doi.org/10.3390/dj12040112 - 17 Apr 2024
Cited by 10 | Viewed by 4494
Abstract
By correctly repositioning teeth, orthodontic therapy improves both the function and appearance of an occlusion. The relationship between teeth and the tissues that surround and support them significantly influences these alterations. With ever more adults seeking orthodontic care, orthodontists are increasingly seeing patients [...] Read more.
By correctly repositioning teeth, orthodontic therapy improves both the function and appearance of an occlusion. The relationship between teeth and the tissues that surround and support them significantly influences these alterations. With ever more adults seeking orthodontic care, orthodontists are increasingly seeing patients with periodontal issues. Concerns about the patient’s appearance, such as uneven gingival margins or functional issues caused by inflammatory periodontal diseases, should be accounted for when designing orthodontic treatment plans. Furthermore, orthodontics may increase the chances of saving and recovering a degraded dentition in cases of severe periodontitis. Today, general dentists, dontists, and orthodontists play integrative roles that enable them to achieve the best possible results for their patients. This review will improve the results of interdisciplinary treatments and increase cooperation between dental specialists by drawing attention to the essential connection between orthodontics and periodontics in regular clinical practice. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional Treatment in Periodontitis Patients - A Special Challenge?)
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Other

Jump to: Research, Review

13 pages, 2340 KiB  
Opinion
Oral Medicine and Oral Clinical Chemistry Game Changers for Future Plaque Control and Maintenance: PerioSafe® aMMP-8 POCT, Lumoral® 2× PDT- and Lingora® Fermented Lingonberry Oral Rinse-Treatments
by Nur Rahman Ahmad Seno Aji, Vaibhav Sahni, Miika T. Penttala, Dimitra Sakellari, Andreas Grigoriadis, Tommi Pätilä, Pirjo Pärnänen, Dirk Neefs, Andreas Pfützner, Shipra Gupta, Timo Sorsa and Ismo T. Räisänen
Dent. J. 2025, 13(3), 127; https://doi.org/10.3390/dj13030127 - 13 Mar 2025
Viewed by 668
Abstract
Background: Periodontitis is a global health crisis that affects almost half of the world’s population and commonly goes unnoticed because of its asymptomatic and pain-free nature. For early and easy detection and treatment, safe and non-invasive chair-side oral fluid biomarker (aMMP-8) diagnostics [...] Read more.
Background: Periodontitis is a global health crisis that affects almost half of the world’s population and commonly goes unnoticed because of its asymptomatic and pain-free nature. For early and easy detection and treatment, safe and non-invasive chair-side oral fluid biomarker (aMMP-8) diagnostics and new anti-microbial, anti-inflammatory and anti-proteolytic treatment modalities have been developed, which this review aims to introduce. Methods: For convenient diagnosis and tackling of periodontitis, adoption of an oral fluid aMMP-8 chair-side point-of-care rapid diagnostic test (POCT) has been proposed, comparable to home pregnancy and COVID-19 antigen tests, to be conveniently used by healthcare professionals and by patients themselves. To improve treatment of detected periodontitis, Finnish scientists have also developed a potentially industry-altering, biofilm-modulating, anti-microbial, anti-inflammatory, and anti-proteolytic (i) dual-light-activated photodynamic-therapy (2×PDT) and (ii) fermented lingonberry juice (FLJ) oral rinse designed for home personalized medicine and professional use. These new oral medicine technologies are reviewed and some unpublished results are presented. Results: aMMP-8 is the superior biomarker for grade of periodontitis (progression rate) when compared to the total latent/proform MMP-8 (total-MMP-8) and microbial lipopolysaccharide (LPS/LAL) activity. Cut-off 20 ng/mL is the optimal cut-off for aMMP-8 POCT and does not make false positives. Antibacterial 2× PDT light and anti-microbial FLJ treatments can eliminate and reduce problem-causing bacteria and Candida-yeasts from the mouth. Conclusions: These new oral medicine technologies have shown promising results and could have the potential to revolutionize diagnosis, prevention, oral care, plaque control and maintenance. These new game-changer oral medicine technologies have launched a new clinical field in dentistry: oral clinical chemistry. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Inflammation Prophylaxis, Aesthetic and Functional Treatment in Periodontitis Patients - A Special Challenge?)
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