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Dentistry Journal
Special Issues
Regenerative Dentistry: Innovations and Clinical Applications
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Regenerative Dentistry: Innovations and Clinical Applications

A special issue of Dentistry Journal (ISSN 2304-6767).

Deadline for manuscript submissions: 20 May 2026 | Viewed by 2843

Special Issue Editors

Dr. Nima Farshidfar

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Guest Editor
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
Interests: tissue regeneration; biomaterials; stem cells; periodontology; implant dentistry; regenerative dentistry
Dr. Richard Miron

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Guest Editor
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
Interests: platelet-rich fibrin; exosomes; growth factors; bone grafts; cell biology; regeneration
Dr. Jean Claude Imber

E-Mail Website
Guest Editor
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
Interests: periodontal regeneration; bone regeneration; periodontology; implant dentistry; histology

Special Issue Information

Dear Colleagues,

Tissue engineering has played a pivotal role in advancing regenerative medicine by enabling biologically driven strategies to repair, regenerate, and restore damaged tissues. By integrating scaffolds, biological factors, and cells, it aims not only to promote true regeneration but also to maintain or improve tissue function. In regenerative dentistry, these principles have been applied to restore dental, oral, and craniofacial tissues. This shift has led to more predictable and durable clinical outcomes, opening new possibilities for biologically based therapies in dentistry.

With the rapid advancement of novel biomaterials, biological factors, cell-based therapies, and cutting-edge technologies, regenerative dentistry is progressing at an unprecedented pace. To ensure the safety, efficacy, and clinical relevance of these innovations, critical evaluation is essential. This Special Issue, titled“Regenerative Dentistry: Innovations and Clinical Applications”, aims to bring together pioneering preclinical studies, clinical research, and technological developments that are shaping the future of regenerative dental care.

With this, we warmly invite you to submit your original research articles, review articles, and other contributions related to preclinical and clinical research in the field of regenerative dentistry.

Dr. Nima Farshidfar
Dr. Richard Miron
Dr. Jean Claude Imber
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative dentistry
  • tissue engineering
  • oral and maxillofacial tissue regeneration
  • periodontal and bone regeneration
  • pulp regeneration
  • stem cells
  • biomaterials
  • biological factors
  • implant dentistry
  • technologies for regenerative dentistry
  • artificial intelligence for regenerative dentistry

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  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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15 pages, 25878 KB  
Article
The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part One: Technical Development of Protocols
by Nathan E. Estrin, Alan Rene Espinoza, Paras Ahmad, Jean-Claude Imber, Nima Farshidfar and Richard J. Miron
Dent. J. 2025, 13(12), 604; https://doi.org/10.3390/dj13120604 - 16 Dec 2025
Cited by 1 | Viewed by 1407
Abstract
Background: Platelet-rich fibrin (PRF) is an autologous biomaterial utilized as an adjunct in dental implant surgeries owing to its significant biocompatibility, supra-physiological concentration of growth factors, and ability to speed either soft or hard tissue regeneration. Methods: Today, PRF is available in both [...] Read more.
Background: Platelet-rich fibrin (PRF) is an autologous biomaterial utilized as an adjunct in dental implant surgeries owing to its significant biocompatibility, supra-physiological concentration of growth factors, and ability to speed either soft or hard tissue regeneration. Methods: Today, PRF is available in both solid and liquid forms with an average resorption period of roughly 2 weeks. While various research endeavors have attempted to utilize Solid-PRF as a barrier membrane in guided bone regeneration (GBR) and various other applications, its two-week resorption period has limited its use as a solo “barrier” membrane owing to its faster-than-ideal resorption properties. Results: Recent studies have demonstrated that by heating and denaturing Liquid-PRF/albumin, the resorption properties of the heated albumin gel could be extended from 2 weeks to 4–6 months by utilizing the Bio-Heat technology. This emerging technology was given the working name ‘extended-PRF’ or e-PRF, with many clinical indications being proposed for further study. Numerous clinicians have now utilized extended-PRF (e-PRF) membranes as a substitute for collagen barrier membranes in various clinical applications, such as guided tissue/bone regeneration, recession coverage, and lateral window sinus lifts. Conclusions: This two-part case series paper aims to first illustrate the evolution of techniques developed taking advantage of this new technology in clinical practice for alveolar ridge preservation. This includes four different methods of fabrication of e-PRF along with its application in clinical practice. This article discusses the clinical outcomes, including the advantages/disadvantages of utilizing each of the four separate techniques to prepare and utilize e-PRF membranes for ridge preservation. Full article
(This article belongs to the Special Issue Regenerative Dentistry: Innovations and Clinical Applications)
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10 pages, 951 KB  
Case Report
Direct Pulp Capping of Dental Pulp with Two Different Autologous Platelet Concentrates A-PRF+ and H-PRF—A Report on Two Cases
by Janet Kirilova and Dimitar Yovchev
Dent. J. 2026, 14(1), 48; https://doi.org/10.3390/dj14010048 - 12 Jan 2026
Viewed by 705
Abstract
Background: Autologous platelet concentrates, including platelet-rich fibrin (PRF) matrices, have been proposed as biologically active scaffolds for vital pulp therapy. Evidence on the clinical use of different solid PRF matrices for direct pulp capping remains limited. Objective: The aim of this [...] Read more.
Background: Autologous platelet concentrates, including platelet-rich fibrin (PRF) matrices, have been proposed as biologically active scaffolds for vital pulp therapy. Evidence on the clinical use of different solid PRF matrices for direct pulp capping remains limited. Objective: The aim of this study is to describe and monitor two clinical cases of reversible pulpitis treated with direct pulp capping using two PRF membranes prepared by different centrifugation approaches, namely advanced platelet-rich fibrin plus (A-PRF+) and horizontal platelet-rich fibrin plus (H-PRF). Methods: In Case 1, A-PRF+ was prepared using a fixed-angle centrifugation protocol; in Case 2, H-PRF was prepared using a horizontal centrifugation protocol. In both cases, deep carious lesions with small carious pulp exposures (<1.5 mm) were managed by caries removal, ozone-assisted dentin disinfection, and direct pulp capping with the respective PRF membrane, followed by temporary calcium-silicate cement definitive coronal restoration. Clinical and radiographic follow-up, including cone-beam computed tomography, was performed for up to 12 months. Results: In Case 1 (A-PRF+), reparative dentin bridge formation was confirmed at 90 days, with a thickness of 0.2 mm. In Case 2 (H-PRF), reparative dentin was observed within 46 days, with a thickness of 0.28 mm. In both cases, pulp vitality was maintained, and no clinical symptoms or periapical changes were detected during the 12-month follow-up. Conclusions: These two cases suggest that direct pulp capping using PRF membranes (A-PRF+ or H-PRF), combined with ozone-assisted dentin disinfection and adequate coronal sealing, may be associated with maintained pulp vitality and hard-tissue repair after carious pulp exposure diagnosed as reversible pulpitis. Due to the descriptive two-case design and major confounding factors (including age and lesion characteristics), no comparative conclusions can be drawn. Prospective controlled clinical studies with standardized protocols are warranted. Full article
(This article belongs to the Special Issue Regenerative Dentistry: Innovations and Clinical Applications)
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