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Dentistry Journal
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Feature Review Papers in Dentistry: 2nd Edition
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Feature Review Papers in Dentistry: 2nd Edition

A special issue of Dentistry Journal (ISSN 2304-6767).

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1679

Special Issue Editor

Dr. Christos Rahiotis

E-Mail Website
Guest Editor
Department of Operative Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 115 27 Athens, Greece
Interests: dental caries; dental materials; dentin hypersensitivity; restorative dentistry; sports dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to publish high-quality review papers in the research fields of dentistry. Manuscripts pertinent to basic (experimental), clinical, and epidemiological research questions will be published, following the successful fulfillment of the regular peer-review process, in case they fall within the journal’s scope. All types of reviews will be considered as long as they meet the journal’s standards. We encourage researchers from various fields to contribute review papers highlighting the latest developments in their research field or to invite relevant experts and colleagues to do so.

We look forward to receiving your excellent work.

Dr. Christos Rahiotis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • orthodontics
  • periodontology
  • oral implantology
  • restorative dentistry
  • dental caries
  • dental materials
  • preventive dentistry
  • dentin hypersensitivity
  • sports dentistry
  • digital dentistry
  • dental education

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (3 papers)

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Review

26 pages, 1377 KB  
Review
The Role of Inflammasomes in Chronic Oral Inflammatory Disease and Oral Cancer: A Narrative Review
by Banan Al-Natour, Issam Rasheed and Ikhlas A. El Elkarim
Dent. J. 2025, 13(12), 609; https://doi.org/10.3390/dj13120609 - 18 Dec 2025
Abstract
Background: Chronic inflammation is a hallmark of many oral and systemic diseases and has long been recognised as a risk factor for cancer development. Central to inflammatory responses are inflammasomes—multiprotein complexes that, upon activation, trigger caspase-1–mediated release of the pro-inflammatory cytokines interleukin-1β (IL-1β) [...] Read more.
Background: Chronic inflammation is a hallmark of many oral and systemic diseases and has long been recognised as a risk factor for cancer development. Central to inflammatory responses are inflammasomes—multiprotein complexes that, upon activation, trigger caspase-1–mediated release of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). Their emerging contribution to chronic oral inflammatory conditions has generated interest in understanding whether persistent inflammasome activity may also influence pathways involved in oral carcinogenesis. This review summarises current evidence on the role of inflammasomes in oral inflammatory diseases and explores their potential involvement in the transition from chronic inflammation to malignant transformation. Methods: A narrative review of the literature was conducted by searching major scientific databases for studies investigating inflammasome activation in oral tissues, inflammatory oral diseases, and mechanisms linking chronic inflammation to oral cancer. Eligible articles included experimental studies, animal models, observational clinical research, and review papers that provided mechanistic or associative insights. Due to heterogeneity in study designs, a qualitative synthesis was performed. Results: Available evidence indicates that inflammasomes, particularly NLRP3 and AIM2, contribute to the pathophysiology of pulpitis, periodontitis, and several systemic conditions that affect oral health. Preclinical and observational findings also suggest potential involvement of inflammasome-related pathways in early tumorigenic processes, although these associations require further clarification. Preliminary biomarker-based studies demonstrate that inflammasome components measurable in saliva, pulpal blood, or gingival crevicular fluid may offer minimally invasive indicators of inflammatory burden and oral health status. Conclusions: Inflammasomes appear to play a meaningful role in oral inflammatory diseases, and growing evidence links their persistent activation to mechanisms relevant to oral carcinogenesis. However, current findings are largely associative and derived primarily from experimental and early clinical research. Additional work is needed to define precisely how inflammasomes contribute to the progression from chronic oral inflammation toward malignant change and to evaluate whether targeting inflammasome pathways offers viable therapeutic or diagnostic potential. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry: 2nd Edition)
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Graphical abstract

24 pages, 1018 KB  
Review
Recent Advances in Regenerative Therapies in Periodontology
by Andrei-Mario Bădărău-Șuster, Edwin Sever Bechir, Zsuzsanna Bardocz-Veres, Ana Petra Lazăr, Alexandru Vlasa, Mircea Suciu, Tatiana-Maria Coman and Luminița Lazăr
Dent. J. 2025, 13(12), 564; https://doi.org/10.3390/dj13120564 - 1 Dec 2025
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Abstract
Background/Objectives: Periodontal regeneration remains a primary goal in contemporary periodontal therapy, aiming to restore both the structural and functional integrity of tissues lost due to periodontitis. Recent advancements in biomaterials, growth factors, and biologically active matrices have expanded the therapeutic possibilities in [...] Read more.
Background/Objectives: Periodontal regeneration remains a primary goal in contemporary periodontal therapy, aiming to restore both the structural and functional integrity of tissues lost due to periodontitis. Recent advancements in biomaterials, growth factors, and biologically active matrices have expanded the therapeutic possibilities in clinical practice. This narrative review aimed to summarize recent developments in regenerative approaches in periodontology, emphasizing their biological principles, clinical outcomes, and current limitations. Methods: A literature search was conducted in PubMed Central and Scopus for randomized controlled trials and clinical trials published between January 2015 and July 2025. Human studies in English, available in open access and evaluating periodontal regenerative approaches, were included, while animal, in vitro, and non-clinical studies were excluded. A total of 67 articles met the eligibility criteria. Data were synthesized in both tabular and narrative form. Results: Most trials reported clinically relevant improvements in probing depth reduction, clinical attachment gain, and defect fill when regenerative biomaterials were applied in appropriately selected intrabony defects, although outcomes varied according to defect morphology, surgical protocol, and patient-related factors. Conclusions: Although substantial progress has been made, true periodontal regeneration remains challenging. Regenerative techniques such as GTR/GBR, EMD, platelet concentrates, and hyaluronic acid show favorable outcomes in appropriately selected cases, although overall predictability remains limited by variability in study design and short follow-up periods. High-quality, standardized RCTs are needed to consolidate current evidence and support guideline-based clinical decision-making. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry: 2nd Edition)
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Graphical abstract

15 pages, 286 KB  
Review
Immediate Dentine Sealing: Towards a Surface Science Perspective on an Undercharacterised Adhesive Interface
by Konstantinos Anastasiadis and Emmanouil-George Tzanakakis
Dent. J. 2025, 13(12), 549; https://doi.org/10.3390/dj13120549 - 21 Nov 2025
Viewed by 510
Abstract
Background: Immediate Dentine Sealing (IDS) is a well-established adhesive strategy that protects freshly cut dentine and enhances the clinical performance of indirect restorations. While its mechanical benefits are extensively documented, the surface morphology and chemical nature of the sealed dentine, particularly following [...] Read more.
Background: Immediate Dentine Sealing (IDS) is a well-established adhesive strategy that protects freshly cut dentine and enhances the clinical performance of indirect restorations. While its mechanical benefits are extensively documented, the surface morphology and chemical nature of the sealed dentine, particularly following provisionalisation and reactivation, remain under-characterised. Understanding this bonding substrate is critical for optimising adhesion and long-term outcomes. Methods: This narrative review synthesises the literature on the morphological and chemical features of dentine following IDS, focusing on the distinction between cross-sectional and surface-level characterisation, as well as the analytical techniques employed. Results: Most studies concentrate on internal bond strength and failure analysis, with only a limited subset incorporating surface-sensitive methods such as top-down SEM or optical non-contact profilometry. Quantitative and chemically resolved data on the reactivated dentine surface, the dentine surface after cleaning or abrasion, prior to cementation are scarce, and standardised analytical protocols are lacking. Conclusions: The bonding interface in IDS, namely the reactivated dentine surface, is underexplored. Future research should apply advanced, non-destructive techniques to characterise this clinically relevant substrate and guide the development of adhesive systems tailored to IDS-treated dentine. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry: 2nd Edition)
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