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Cosmetics
Special Issues
Nanoparticles for Cosmetic Use and Their Application
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Nanoparticles for Cosmetic Use and Their Application

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 29980

Special Issue Editors

Dr. Filipa Mascarenhas-Melo

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Guest Editor
1. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal
2. REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal
Interests: nanotechnology; skin; delivery systems; cosmetics; regulatory affairs; topical strategies; nanomaterials; quality management systems; ISO standards; good practices
Special Issues, Collections and Topics in MDPI journals
Dr. Ana Cláudia Paiva-Santos

E-Mail Website
Guest Editor
1. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal
2. REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal
Interests: pharmaceutical technology; nanotechnology; new drug delivery systems; nanosystems; halloysite clay nanotubes; targeted therapies; multifunctional nanoplatforms; combined therapies, anticancer therapies; theranostics; cutaneous melanoma & pancreatic cancer; dermopharmacy and cosmetics; skin care; hair care and topical formulations

Special Issue Information

Dear Colleagues,

Nanotechnology-based strategies are gaining more and more interest and prominence in the field of dermopharmacy and cosmetics. Minimizing systemic side effects and ease of application are some of the main objectives when using topical applications of active ingredients. However, the selection of suitable delivery systems becomes a crucial aspect to achieve proper delivery, which provides better permeation and retention of active ingredients and targets the intended site. At the same time, the concern that these systems minimize skin irritation is a critical factor in this type of topical approach. Thus, nanotechnology strategies, and in particular the use of nanoparticles, have shown strong evidence for improved therapeutic efficacy and reduced side effects, overcoming limitations related to conventional systems of active ingredient delivery. The aim of this Special Issue is to highlight the use of nanoparticles in formulations for cosmetic use, showing the different applications in which they can be used, considering their inherent characteristics, but also their contribution in technological terms as vehicles of active ingredients. In addition, papers addressing the toxicity of nanoparticles, both to humans and the environment, are also of interest for this Special Issue, as well as the contribution and/or impact that nanoparticles may have in terms of environmental, economic and/or social sustainability. Approaches to regulatory issues, regarding the use of these nanomaterials, may also be considered. Both original research papers and review articles will be considered for this Special Issue.

Dr. Filipa Mascarenhas-Melo
Dr. Ana Cláudia Santos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanotechnology
  • cosmetic applications
  • skin
  • dermopharmaceutical formulations

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Published Papers (4 papers)

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Research

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15 pages, 2821 KiB  
Article
Exploring Stearic-Acid-Based Nanoparticles for Skin Applications—Focusing on Stability and Cosmetic Benefits
by Catarina Pereira-Leite, Mariana Bom, Andria Ribeiro, Cíntia Almeida and Catarina Rosado
Cosmetics 2023, 10(4), 99; https://doi.org/10.3390/cosmetics10040099 - 5 Jul 2023
Cited by 7 | Viewed by 4169
Abstract
The outermost layer of the epidermis, the stratum corneum (SC), ensures protection against harmful xenobiotics, and alterations in its lipidic matrix composition are related to several cutaneous dysfunctions. The skin barrier function is usually attributed to ceramides, but the role of free fatty [...] Read more.
The outermost layer of the epidermis, the stratum corneum (SC), ensures protection against harmful xenobiotics, and alterations in its lipidic matrix composition are related to several cutaneous dysfunctions. The skin barrier function is usually attributed to ceramides, but the role of free fatty acids, such as stearic acid, has been increasingly acknowledged. This research work aimed to develop solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) based on stearic acid and glyceryl distearate, in order to explore the potential of these materials as the basis of lipid nanoparticles. Different blends of stearic acid, Precirol® ATO 5, Capryol® 90 and Tween® 80 were probed to prepare SLN and NLC. These lipid nanoparticles were further characterised according to particle size, polydispersity index (PDI), pH, and viscosity. Accelerated and long-term stability tests were also performed for 90 days, as well as in vivo assays to evaluate safety and efficacy. Overall, most nanoparticles showed interesting properties for topical application if they had sizes less than 300 nm, PDI below 0.3, pH compatible with skin and viscosity lower than 5 mPa.s. In long-term stability studies, the SLN_2 and NLC_2 formulations stood out, as they remained stable over time. In vivo biocompatibility tests conducted in human volunteers showed no negative impact of the formulations when applied openly or under occlusion. Efficacy studies with the most stable nanoparticles made of Precirol® ATO 5 showed an increase in skin hydration. The nanoparticles developed in this study have shown potential to be used for cosmetic purposes, and the blend of lipids provided good biocompatibility and moisturising properties. Full article
(This article belongs to the Special Issue Nanoparticles for Cosmetic Use and Their Application)
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14 pages, 3747 KiB  
Article
Enhancement of Skin Permeation and Penetration of β-Arbutin Fabricated in Chitosan Nanoparticles as the Delivery System
by Shariza Sahudin, Nursyafiqah Sahrum Ayumi and Norsavina Kaharudin
Cosmetics 2022, 9(6), 114; https://doi.org/10.3390/cosmetics9060114 - 3 Nov 2022
Cited by 11 | Viewed by 3094
Abstract
Background: There has been an increase in demand for cosmetic skin-whitening products with efficacy toward lightening skin tone. β-arbutin is an inhibitor of tyrosinase enzyme activity within the skin’s melanocytes, and so has shown considerable promise as a skin-lightening agent. It is, however, [...] Read more.
Background: There has been an increase in demand for cosmetic skin-whitening products with efficacy toward lightening skin tone. β-arbutin is an inhibitor of tyrosinase enzyme activity within the skin’s melanocytes, and so has shown considerable promise as a skin-lightening agent. It is, however, both hydrophilic and hygroscopic, which hinders its penetration of the skin to reach these melanocytes. Chitosan (CS) possesses considerable penetration-enhancing properties when utilized in topical delivery formulations. The strong affinity of positively charged chitosan nanoparticles toward negatively charged biological membranes can be exploited to achieve site-specific targeting. Objective: To investigate the use of chitosan nanoparticles (CSNPs) as carrier units to enhance the topical delivery of β-arbutin. Method: CSNPs containing β-arbutin were prepared using an ionic cross-linking method, and entrapment efficiency and loading capacity were evaluated at numerous β-arbutin concentrations. Further characterization involved using FTIR, XRD, TEM, and TGA, and in vitro permeation studies were conducted using in vitro Franz diffusion cells. Results: β-arbutin chitosan nanoparticles were successfully formulated with a size range of 211–289 d.nm, a polydispersity index between 0.2–0.3, and zeta potential in the range 46.9–64.0 mV. The optimum encapsulation efficiency (EE) and loading capacity (LC) of β-arbutin were 68% and 73%, respectively. TEM revealed the nanoparticles to be spherical in shape. FTIR spectra revealed characteristic chitosan-related peaks appearing at 3438.3 cm−1 (-OH stretching) and 3320 cm−1 (-CH stretching), together with 1598.01 cm−1 (-NH2) specific to β-arbutin nanoparticles. XRD analysis revealed an increase in crystallinity and TGA analyses identified increasing thermal stability with increasing β-arbutin concentration. In vitro studies indicated higher permeation and improved penetration of β-arbutin loaded in CSNPs compared to its free form. Conclusion: CSNPs present considerable promise as effective carriers for improved topical delivery of β-arbutin. Full article
(This article belongs to the Special Issue Nanoparticles for Cosmetic Use and Their Application)
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Review

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14 pages, 581 KiB  
Review
Nanomaterials in Cosmetics: An Outlook for European Regulatory Requirements and a Step Forward in Sustainability
by Laura Ferreira, Patrícia C. Pires, Mariana Fonseca, Gustavo Costa, Prabhanjan Shridhar Giram, Priscila Gava Mazzola, Victoria Bell, Filipa Mascarenhas-Melo, Francisco Veiga and Ana Cláudia Paiva-Santos
Cosmetics 2023, 10(2), 53; https://doi.org/10.3390/cosmetics10020053 - 24 Mar 2023
Cited by 12 | Viewed by 6118
Abstract
The use of materials and products that improve appearance and provide comfort and well-being goes back to the beginning of civilization. Cosmetics is an evolving market that has increasingly focused on innovative technological approaches. Nanotechnology is one of the most revolutionary and promising [...] Read more.
The use of materials and products that improve appearance and provide comfort and well-being goes back to the beginning of civilization. Cosmetics is an evolving market that has increasingly focused on innovative technological approaches. Nanotechnology is one of the most revolutionary and promising fields for the development of novel and enhanced cosmetic products, owing to the remarkable multifunctional characteristics and effects of nanomaterials (NMs). Their application, however, also raises potential safety concerns. Some of these concerns can be addressed by determining the type of NMs used, as well as their stability, potential for skin absorption, route of exposure, and how they are formulated into cosmetic products. To guarantee such safety, cosmetic products containing NMs, must comply with European regulatory provisions, particularly the European Regulation (EC) n.° 1223/2009 of the European Parliament and of the Council. Hence, this review comprises all the particularities of NMs, their influence on human health, challenges towards environmental sustainability, and strategies to harmonize policies with the aim to normalize their application in cosmetics. Full article
(This article belongs to the Special Issue Nanoparticles for Cosmetic Use and Their Application)
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32 pages, 3063 KiB  
Review
The Advancement of Herbal-Based Nanomedicine for Hair
by Komal Padule, Sonali Shinde, Sohan Chitlange, Prabhanjan Giram and Dheeraj Nagore
Cosmetics 2022, 9(6), 118; https://doi.org/10.3390/cosmetics9060118 - 11 Nov 2022
Cited by 2 | Viewed by 15076
Abstract
Polymer, lipid, and natural protein-based hair care nanocarriers are in preclinical testing. Nanomedicine has enhanced therapeutic efficacy and decreased side effects. This review examines herbal nanomedicine for hair care. We also reviewed the hair cycle, its morphology, and the mechanisms of herbal-based medicine [...] Read more.
Polymer, lipid, and natural protein-based hair care nanocarriers are in preclinical testing. Nanomedicine has enhanced therapeutic efficacy and decreased side effects. This review examines herbal nanomedicine for hair care. We also reviewed the hair cycle, its morphology, and the mechanisms of herbal-based medicine that regulate the hair cycle to treat hair loss. Nano-formulations have better solubility, permeability, therapeutic efficacy, and prolonged distribution than standard herbal medicines. This review also discussed the nanotechnology barrier and nano formulations for hair loss and growth and includes a recent herbal nanomedicine study. Researchers interested in using herbs to treat hair problems and clinically translating hair care products may find the results presented significant. Full article
(This article belongs to the Special Issue Nanoparticles for Cosmetic Use and Their Application)
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