Special Issue "Simulation, Imaging and Modelling for Biomedical Systems"

A special issue of Computers (ISSN 2073-431X).

Deadline for manuscript submissions: 15 December 2019

Special Issue Editors

Guest Editor
Dr. Elena Casiraghi

Department of Computer Science; Università degli Studi di Milano
Website | E-Mail
Interests: artificial intelligence; pattern recognition; microscopy and histological image analysis; physiology models; biomedical image analysis; computer-aided diagnosis (CAD) systems; color sensation and perception; image enhancement and visualization
Guest Editor
Dr. Barbara Barricelli

Department of Computer Science; Università degli Studi di Milano
Website | E-Mail
Interests: human–computer interactions (HCI); user-centered design (UCD); end-user development (EUD); user-centered computing (UCC); user eXperience (UX); internationalization and localization of interactive systems; computer semiotics and semiotic engineering; creative and participatory design; color sensation and perception

Special Issue Information

Dear Colleagues,

Over the past decades, a continuous increase in computational power, together with substantial advances in the digital image processing and pattern recognition fields, has motivated the development of computer-aided diagnostic (CAD) systems, augmented and virtual reality applications for surgical planning and simulation, and digital-twin applications for healthcare. Thanks to their effective, precise, and repeatable results, validated CAD systems are nowadays exploited as a valid aid during diagnostic procedures. Surgical simulation applications have become an essential part of surgical procedures as well as training, while research on the development of digital-twin applications in healthcare is continuously increasing, to deliver significant societal and health benefits.

Similar important advances in the field of microscopy image analysis have been motivated by the advent of digital microscopes producing high-resolution digital images. Indeed, in the past thirty years the development of computerized systems that have helped pathologists in their analysis of images obtained by fluorescence, histochemical, and immunohistochemical labeling has become a main research focus for computer scientists and clinicians. State-of-the-art automatic microscopy image analysis systems automatically identify biological structures of interest and then try to reproduce the evaluation and quantification performed by expert pathologists and clinicians. These tools are much appreciated in the field for their potential to minimize the inherent subjectivity of manual analysis and to largely reduce the workload of clinicians via high-throughput analysis.

This Special Issue intends to provide a comprehensive overview of recent, theoretical, and/or practical advances and new trends in biomedical/microscopy image enhancement and analysis, vision modelling, and general physiological models applied to biomedical/microscopy image processing and advanced visualization methods and devices, and to discuss their applications in the biological and medical fields.

Dr. Elena Casiraghi
Dr. Barbara Barricelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Computers is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • BioMedical/microscopy image enhancement
  • Biomedical/microscopy image quality assessment
  • Biomedical/microscopy image analysis
  • Computational approaches for citology and histology
  • Computer-aided diagnosis
  • Neuro imaging
  • BioMedical/microscopy image databases
  • Machine learning and artificial intelligence
  • Image segmentation, registration, and fusion
  • Interventional imaging systems
  • Image-guided interventions and surgery
  • Surgical and interventional simulation systems
  • Interventional tracking and navigation
  • Surgical planning and simulation
  • Surgical visualization and mixed, augmented and virtual reality
  • Digital twins and end-user development in biomedicine
  • Interventional software and user interfaces
  • Physiological models

Published Papers

This special issue is now open for submission.
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