Application of Nanoparticles in Drug Delivery and Cancer Therapy
A special issue of Coatings (ISSN 2079-6412).
Deadline for manuscript submissions: closed (10 November 2022) | Viewed by 1610
Special Issue Editor
Special Issue Information
Dear Colleagues,
Research in the field of nanomaterials for biomedical applications, particularly for drug delivery in cancer therapeutics, has garnered immense attention in the past few decades due to their versatile functional and structural capabilities. This encompasses a vast field of research, including hard-metal-based nanoparticles, polymeric nanocarriers, protein conjugates, polyplexes, naturally occurring biomaterials and supramolecular systems. Although the pharmacological industry invests immensely in the design and discovery of novel drug molecules, small molecular drugs are often inefficient at targeting many diseases, such as deep-seated low-vasculature tumors, metastasized cancers and various autoimmune diseases. Coupled with a rapid clearance rate, low solubility, drug resistance and high off-target toxicity, these small molecular drugs often present modest benefits for a host of common diseases. In order to improve the therapeutic index of pre-existing drugs and shortening the translation from preclinical validation to clinical approval, a vast area of drug delivery research focuses on the improvement of drug carriers by various alterations. The major challenges currently faced by drug delivery systems include a low payload, transition through the desmoplastic barrier for solid tumors and high hepatic and renal clearance. In order to address these issues, numerous biocompatible nanomaterials have been engineered and have been reported to enhance the stability and pharmacokinetic properties of the active drugs. Ongoing efforts in this field are promising, and may open new horizons for personalized medicine for effective cures for cancer. We invite research articles in the field of nanomaterials used for drug delivery as a potential cure for cancer. This Special Issue will include all aspects of research related to nanoparticles as drug carriers and application-oriented papers, experimental and numerical studies, case studies and reviews.
In particular, the topics of interest include but are not limited to:
- Nanomaterials;
- Drug delivery agents;
- Cancer therapeutics
- Polymeric particles;
- Biomaterials for drug delivery;
- Novel delivery agents;
- Biocompatible nanomaterials;
- Targeted therapy.
Dr. Priyanka Ray
Guest Editor
Manuscript Submission Information
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Keywords
- cancer therapy
- nanoparticles
- polymersomes
- drug delivery
- nanobiomaterials
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