Advances in Thromboembolism: Precision Prevention and Clinical Management

A special issue of Clinics and Practice (ISSN 2039-7283).

Deadline for manuscript submissions: 31 August 2026 | Viewed by 295

Special Issue Editors


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Guest Editor
1. Servicio de Medicina Interna, Hospital Universitario Infanta Leonor-Virgen de la Torre, Madrid, Spain
2. Unidad de Tromboembolismo Venoso, Hospital Universitario Infanta Leonor-Virgen de la Torre, Madrid, Spain
Interests: venous thromboembolism; precision risk stratification; thrombosis in special populations; radiomics; digital twin simulation models; explainable machine learning approaches
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Internal Medicine, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain
Interests: oral anticoagulants

Special Issue Information

Dear Colleagues,

Venous thromboembolism remains a leading cause of morbidity and mortality worldwide. In recent years, the field has advanced toward individualized approaches through a better understanding of pathophysiological mechanisms, risk stratification tools, and the emergence of precision medicine. The incorporation of biomarkers, machine learning, and refined clinical prediction models has paved the way for more accurate risk assessment and the development of tailored prevention strategies.

This Special Issue aims to gather original research and high-quality reviews that explore the full spectrum of thromboembolism, from molecular mechanisms and innovative diagnostic tools to novel therapeutic strategies. We particularly welcome contributions focusing on special clinical scenarios, such as cancer-associated thrombosis, thrombosis in transgender populations, and pregnancy, as well as studies incorporating artificial intelligence or real-world data.

We invite you to submit original articles, reviews, meta-analyses, and clinical studies related to the mechanisms, diagnosis, risk prediction, and personalized management of thromboembolic disease.

Dr. Anabel Isabel Franco-Moreno
Guest Editor

Dr. Cristina Lucía de Ancos Aracil
Guest Editor Assistant

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • venous thromboembolism
  • biomarkers
  • risk stratification
  • anticoagulation
  • artificial intelligence
  • precision medicine
  • special populations
  • real-world evidence
  • thrombosis prevention

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Published Papers (1 paper)

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Research

12 pages, 1208 KB  
Article
Impact of Carotid Artery Tortuosity on Technical Aspects of Endovascular Thrombectomy in a Newly Established Thrombectomy-Capable Stroke Center
by Katja Lovoković, Vjekoslav Kopačin, Mihael Mišir, Mateo Grigić, Domagoj Matijević, Tatjana Rotim, Domagoj Kretić, Damir Štimac, Anja Tomić, Lucija Čolaković and Tajana Turk
Clin. Pract. 2025, 15(10), 183; https://doi.org/10.3390/clinpract15100183 - 1 Oct 2025
Abstract
Background/Objectives: Blood vessel tortuosity can complicate endovascular procedures such as endovascular thrombectomy in acute ischemic stroke. This study aimed to assess the morphometric characteristics of carotid arteries and investigate the association between the tortuosity of the carotid arteries and the technical aspects [...] Read more.
Background/Objectives: Blood vessel tortuosity can complicate endovascular procedures such as endovascular thrombectomy in acute ischemic stroke. This study aimed to assess the morphometric characteristics of carotid arteries and investigate the association between the tortuosity of the carotid arteries and the technical aspects of endovascular thrombectomy, patient demographics and clinical characteristics, and treatment outcome. Methods: This retrospective study included 84 patients with ischemic stroke treated by endovascular thrombectomy at the newly established thrombectomy-capable stroke center. The following data were collected from prethrombectomy computed tomography angiography: aortic arch type, type of carotid artery tortuosity, and tortuosity index (TI). The technical aspects of the procedure, as well as patient demographics, were collected from the radiological information system. Results: Time from arterial puncture to the first pass was significantly shorter in patients with a nontortuous carotid artery compared to a tortuous one (p = 0.006). There were no significant differences in the number of passes, total duration of the procedure, and the difference in National Institutes of Health Stroke Scale (NIHSS) score before and after the procedure regarding the form of tortuosity. Patients with hypertension had significantly higher tortuosity index values compared to those without hypertension (p = 0.008), and patients with a nontortuous carotid tree were significantly younger compared to those with all forms of tortuosity (p = 0.003). Conclusions: The majority of patients had tortuous carotid arteries, which were associated with older age and hypertension. A high index of tortuosity was associated with a longer time from arterial puncture to the first pass, but not to the treatment outcome. Preprocedural recognition of carotid artery tortuosity may aid in endovascular thrombectomy procedural planning. Full article
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