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Children
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Advances in Theranostic Ultrasound
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Advances in Theranostic Ultrasound

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 1489

Special Issue Editor

Dr. Misun Hwang

E-Mail Website
Guest Editor
Department of Radiology, Childrens Hospital of Philadelphia, Philadelphia, PA 19104, USA
Interests: ultrasound; diagnostic; therapeutic; pediatric

Special Issue Information

Dear Colleagues,

I am excited to share my role as the Guest Editor for this Special Issue of Children, entitled “Advances in Theranostic Ultrasound”. Ultrasound has been a widely used diagnostic tool for children and serves as a convenient, cost-effective tool. Over the years, rapid advancements in diagnostic and therapeutic (theranostic) uses of ultrasound have emerged. As a result, ultrasound is not only a tool of convenience and low cost, but which can yield high resolution anatomic and functional insights into disease processes, and can modulate ultrasound pulses for therapy and drug delivery.

The goal of the Special Issue is to provide a comprehensive overview of the current and emerging techniques in theranostic ultrasound. We invite investigators to contribute original research articles, as well as review articles that will further our understanding of the topic and help propel this field forward. As the title implies, new developments, and unconventional or inspirational contributions are also highly encouraged.

We look forward to receiving your contributions.

Dr. Misun Hwang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ultrasound
  • diagnostic
  • therapeutic
  • pediatric
  • super resolution
  • ultrasound-guided delivery
  • microbubbles

Published Papers (1 paper)

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Research

9 pages, 256 KiB  
Article
Ultrasonography Causes Agitation and Pain Leading to Hemodynamic Disturbance in Neonates: A Prospective Observational Study
by Emre Dincer, Hamza Özer, Sevilay Topçuoğlu and Güner Karatekin
Children 2023, 10(2), 347; https://doi.org/10.3390/children10020347 - 10 Feb 2023
Viewed by 1156
Abstract
Background: Ultrasonography is widely used in neonatological practice and studies investigating the hemodynamic effects of various treatment protocols or clinical situations. On the other hand, pain causes changes in the cardiovascular system; so, in the case of ultrasonography leading to pain in neonates, [...] Read more.
Background: Ultrasonography is widely used in neonatological practice and studies investigating the hemodynamic effects of various treatment protocols or clinical situations. On the other hand, pain causes changes in the cardiovascular system; so, in the case of ultrasonography leading to pain in neonates, it may cause hemodynamic alterations. In this prospective study, we evaluate whether ultrasonographic application causes pain and changes in the hemodynamic system. Methods: Newborns undergoing ultrasonographic examination were enrolled in the study. Vital signs, cerebral and mesenteric tissue oxygenation (StO2) levels, and middle cerebral artery (MCA) Doppler measurements were recorded, and NPASS scores were calculated before and after ultrasonography. Results: We enrolled 39 patients in the study. After ultrasonography, Neonatal Pain, Agitation, and Sedation Scale (NPASS) scores were significantly higher (p < 0.01), and all vital signs (heart rate, respiratory rate, SpO2, diastolic and systolic blood pressure; p = 0.03; p < 0.01, p < 0.01, p < 0.01, p = 0.02, p = 0.03, respectively) were altered. Cerebral (p = 0.008) and mesenteric (p = 0.039) StO2 levels were significantly lower in the whole study group, MCA end-diastolic velocity decreased (p = 0.02), and the resistive index (p = 0.03) increased in patients whose NPASS score was >7 after ultrasonography. Conclusions: This study is the first to show that ultrasonography may cause pain in newborn patients, and alters vital signs and hemodynamic parameters. Therefore, precautions should be taken to protect newborn babies from pain during ultrasound applications, as they are already exposed to many noxious stimuli. Furthermore, pain scores should be considered in studies using ultrasonography and evaluating hemodynamic parameters to increase the reliability of the studies. Full article
(This article belongs to the Special Issue Advances in Theranostic Ultrasound)
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