Acute Lymphoblastic Leukemia: Clinical Implications and Novel Therapeutic Approaches
A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Hematology & Oncology".
Deadline for manuscript submissions: 25 July 2026 | Viewed by 1
Special Issue Editors
Interests: pediatric blood cancers; leukemia and lymphoma
Special Issue Information
Dear Colleagues,
Acute lymphoblastic leukemia is the most common childhood malignancy, with a 5-year overall survival rate of approximately 90%. This success is attributed to advances in multi-modal therapeutic interventions based on patient characteristics that have prognostic implications informing appropriate risk stratification. Nonetheless, many challenges persist, including access to care, treatment-related toxicity, disease relapse, and late-effect burden among survivors. This Special Issue aims to highlight ongoing work aimed at maintaining excellent outcomes among children with favorable disease characteristics while reducing treatment-related morbidity. Additionally, this Special Issue will review novel therapeutic approaches designed to improve outcomes for children with less favorable prognostic factors, including being younger than 1 year old at diagnosis, having Down's syndrome, having high-risk cytogenetic findings, and having a suboptimal disease response. Furthermore, this Special Issue aims to explore the options for patients with disease recurrence. In addition, there will be a focus on health equity and social determinants of health in terms of access to acute intervention and across the care continuum, specifically extending to survivorship care. The goal is to bridge discovery at the bench to delivery at the bedside by integrating basic science and clinical research to provide insight, foster innovation, and ensure collaboration in the care of children diagnosed with ALL.
Dr. Stephanie Massaro
Dr. Neil J. Grossman
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pediatric acute lymphoblastic leukemia
- risk stratification and genomics
- therapeutics—chemotherapy, immunotherapy and targeted therapies
- health equity
- survivorship and late effects
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