Feature Paper

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: closed (31 July 2015) | Viewed by 31496

Special Issue Editor

US Naval Research Laboratory, 4555 Overlook Ac SW, Washington, DC 20375, USA
Interests: bionanotechnology; nanoparticle; energy transfer; enzyme; kinetics; cell-free synthetic biology; biocatalysis; bioconjugation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We plan to publish a Special Issue on "feature papers" in order to give a broad overview of our area. We are looking for top quality papers which will be published free of charge in Open Access form. Authors will be the editorial board members and researchers invited by the editorial office and the Editor-in-Chief. Papers could be both extensive research papers and papers describing the current state of the art in one of the areas covered by the journal.

Prof. Dr. Igor Medintz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • pH sensors, acid-base indicators
  • environment detectors, smoke detector
  • nanosensors
  • sensing materials
  • optical chemical sensors
  • biosensor and chemical sensors networks
  • medical analyzers
  • chemical field-effect transistors
  • new technologies with possibilities for chemosensing

Published Papers (4 papers)

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Research

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460 KiB  
Article
Electrochemical Sensors for the Estimation of the Inhibitory Effect of Phenylcarbamates to Cholinesterase
by Katarína Vorčáková, Šárka Štěpánková, Miloš Sedlák and Karel Vytřas
Chemosensors 2015, 3(4), 274-283; https://doi.org/10.3390/chemosensors3040274 - 10 Dec 2015
Cited by 3 | Viewed by 4371
Abstract
The inhibitory effect of nine phenylcarbamates with various substituents was studied. For this purpose, electrochemical sensors were applied under two different conditions: if an enzyme was present in the solution or if the enzyme was immobilized onto the electrode surface. In both cases, [...] Read more.
The inhibitory effect of nine phenylcarbamates with various substituents was studied. For this purpose, electrochemical sensors were applied under two different conditions: if an enzyme was present in the solution or if the enzyme was immobilized onto the electrode surface. In both cases, 3-[(ethoxycarbonyl)amino]phenyl (4-chloro-phenyl)carbamate was found as the most effective inhibitor for butyrylcholinesterase. The best inhibitors for acetylcholinesterase were determined as well, depending on the used method. Thus, 3‑[(butoxycarbonyl)-amino]phenyl phenylcarbamate with the enzyme present in the solution and 3-[(ethoxycarbonyl)amino]phenyl (3-methylphenyl)carbamate when the enzyme was immobilized onto the electrode surface were evaluated as the most effective inhibitors. Michaelis constants as well as maximum reaction rates were calculated and assessed. Full article
(This article belongs to the Special Issue Feature Paper)
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895 KiB  
Article
Steady-State Fluorescence and Lifetime Emission Study of pH-Sensitive Probes Based on i-motif Forming Oligonucleotides Single and Double Labeled with Pyrene
by Anna Dembska, Patrycja Rzepecka and Bernard Juskowiak
Chemosensors 2015, 3(3), 211-223; https://doi.org/10.3390/chemosensors3030211 - 23 Sep 2015
Cited by 6 | Viewed by 6697
Abstract
Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-state and time-resolved fluorescence studies of pyrene-labeled probes based on RET [...] Read more.
Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-state and time-resolved fluorescence studies of pyrene-labeled probes based on RET sequence: C4GC4GC4GC4TA (RET21), AC4GC4GC4GC4TA (RET21A) and C4GC4GC4GC4T (RET20). Comparative studies with single- and double-labeled i-motif probes were carried out. For each probe, we have measured fluorescence spectra and decays for emission wavelength of 390 nm over a wide range of pH (from 4.0 to 8.0). Effect of the oligonucleotide sequence and the number of pyrene labels on the spectral characteristics of probes were discussed. Full article
(This article belongs to the Special Issue Feature Paper)
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Review

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784 KiB  
Review
New Nanomaterials and Luminescent Optical Sensors for Detection of Hydrogen Peroxide
by Natalia A. Burmistrova, Olga A. Kolontaeva and Axel Duerkop
Chemosensors 2015, 3(4), 253-273; https://doi.org/10.3390/chemosensors3040253 - 26 Oct 2015
Cited by 31 | Viewed by 8647
Abstract
Accurate methods that can continuously detect low concentrations of hydrogen peroxide (H2O2) have a huge application potential in biological, pharmaceutical, clinical and environmental analysis. Luminescent probes and nanomaterials are used for fabrication of sensors for H2O2 [...] Read more.
Accurate methods that can continuously detect low concentrations of hydrogen peroxide (H2O2) have a huge application potential in biological, pharmaceutical, clinical and environmental analysis. Luminescent probes and nanomaterials are used for fabrication of sensors for H2O2 that can be applied for these purposes. In contrast to previous reviews focusing on the chemical design of molecular probes for H2O2, this mini-review highlights the latest luminescent nanoparticular materials and new luminescent optical sensors for H2O2 in terms of the nanomaterial composition and luminescent receptor used in the sensors. The nanomaterial section is subdivided into schemes based on gold nanoparticles, polymeric nanoparticles with embedded enzymes, probes showing aggregation-induced emission enhancement, quantum dots, lanthanide-based nanoparticles and carbon based nanomaterials, respectively. Moreover, the sensors are ordered according to the type of luminescent receptor used within the sensor membranes. Among them are lanthanide complexes, metal-ligand complexes, oxidic nanoparticles and organic dyes. Further, the optical sensors are confined to those that are capable to monitor the concentration of H2O2 in a sample over time or are reusable. Optical sensors responding to gaseous H2O2 are not covered. All nanomaterials and sensors are characterized with respect to the analytical reaction towards H2O2, limit of detection (LOD), analytical range, electrolyte, pH and response time/incubation time. Applications to real samples are given. Finally, we assess the suitability of the nanomaterials to be used in membrane-based sensors and discuss future trends and perspectives of these sensors in biomedical research. Full article
(This article belongs to the Special Issue Feature Paper)
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618 KiB  
Review
Novel Signal-Enhancing Approaches for Optical Detection of Nucleic Acids—Going beyond Target Amplification
by Laura Miotke, Maria Carla Barducci and Kira Astakhova
Chemosensors 2015, 3(3), 224-240; https://doi.org/10.3390/chemosensors3030224 - 23 Sep 2015
Cited by 13 | Viewed by 11134
Abstract
Detection of low-abundance nucleic acids is a challenging task, which over the last two decades has been solved using enzymatic target amplification. Enzymatic synthesis enhances the signal so that diverse, scientifically and clinically relevant molecules can be identified and studied, including cancer DNA, [...] Read more.
Detection of low-abundance nucleic acids is a challenging task, which over the last two decades has been solved using enzymatic target amplification. Enzymatic synthesis enhances the signal so that diverse, scientifically and clinically relevant molecules can be identified and studied, including cancer DNA, viral nucleic acids, and regulatory RNAs. However, using enzymes increases the detection time and cost, not to mention the high risk of mistakes with amplification and data alignment. These limitations have stimulated a growing interest in enzyme-free methods within researchers and industry. In this review we discuss recent advances in signal-enhancing approaches aimed at nucleic acid diagnostics that do not require target amplification. Regardless of enzyme usage, signal enhancement is crucial for the reliable detection of nucleic acids at low concentrations. We pay special attention to novel nanomaterials, fluorescence microscopy, and technical advances in detectors for optical assessment. We summarize sensitivity parameters of the currently available assays and devices which makes this review relevant to the broad spectrum of researchers working in fields from biophysics, to engineering, to synthetic biology and bioorganic chemistry. Full article
(This article belongs to the Special Issue Feature Paper)
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