Special Issue "Palladium-Catalyzed Reactions"

A special issue of Catalysts (ISSN 2073-4344).

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editor

Guest Editor
Dr. Nicola Della Ca' Website E-Mail
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), Parco Area delle Scienze 17/A, University of Parma, 43124—Parma (PR), Italy
Interests: catalytic sequential reactions for the synthesis of high value-added compounds from readily available reagents, transition metal-catalyzed C-H activation methodologies, carbonylation reactions, CO2 activation chemistry

Special Issue Information

Dear Colleagues,

Palladium is probably the most versatile and exploited transition metal in catalysis due to its capability to promote a myriad of organic transformations, both on laboratory and industrial scale. Both homogeneous and heterogeneous palladium-catalyzed reactions continue to play an essential role in organic synthesis. Natural alkaloids, bioactive compounds, pharmaceutical agents, agrochemicals, specialty polymers, etc., can be efficiently accessed by means of palladium catalysts. In general, palladium-based catalysts are involved in a variety of organic reactions, such as alkylation, arylation, cyclization, hydrogenation, oxidation, isomerization, cross-coupling, cascade, radical reactions, etc. Particular attention is devoted to the use of palladium catalysts in C-H bond activation, carbonylation, and asymmetric reactions or in combination with other metals. High chemo- regio- and diastereoselectivities as well as high levels of molecular sophistication can be achieved by employing tailored palladium-based catalytic systems under mild reaction conditions. However, despite these developments, every day new, exciting palladium-based applications are disclosed, giving renewed emphasis to palladium chemistry. Original research papers and reviews focusing on recent advancements in the field of palladium-catalyzed transformations are welcome for inclusion in this Special Issue of Catalysts.

Dr. Nicola Della Ca'
Guest Editor

Manuscript Submission Information

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Keywords

  • Homogeneous and heterogeneous palladium catalysts
  • Pd-catalyzed cascade reactions
  • Pd-catalyzed cross-coupling reactions
  • Pd-catalyzed carbonylation reactions
  • Pd-catalyzed asymmetric reactions

Published Papers (1 paper)

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Research

Open AccessArticle
Synthesis of Mono- and Bis-Pyrazoles Bearing Flexible p-Tolyl Ether and Rigid Xanthene Backbones, and Their Potential as Ligands in the Pd-Catalysed Suzuki–Miyaura Cross-Coupling Reaction
Catalysts 2019, 9(9), 718; https://doi.org/10.3390/catal9090718 - 26 Aug 2019
Abstract
The present work describes the synthesis of mono- and bis-pyrazole compounds bearing flexible p-tolyl ether and rigid 4,5-dibromo-2,7-di-tert-butyl-9,9-dimethyl-9H-xanthene backbones as pyrazolyl analogues of DPEphos and Xantphos ligands, respectively. The synthesis of new pyrazolyl analogues was accomplished following an [...] Read more.
The present work describes the synthesis of mono- and bis-pyrazole compounds bearing flexible p-tolyl ether and rigid 4,5-dibromo-2,7-di-tert-butyl-9,9-dimethyl-9H-xanthene backbones as pyrazolyl analogues of DPEphos and Xantphos ligands, respectively. The synthesis of new pyrazolyl analogues was accomplished following an Ullmann coupling protocol, and the resulting products were isolated in overall good yields. In addition, a hybrid imidazolyl–pyrazolyl analogue bearing a xanthene backbone was synthesized using the same protocol, whereas a hybrid selanyl–pyrazolyl analogue with a xanthene backbone was synthesized in a good yield employing a second C–H activation step. The symmetrical bis-pyrazolyl and the hybrid imidazolyl–pyrazolyl analogues were found to be the most active among the new ligands evaluated in the Pd-catalysed Suzuki-Miyaura cross-coupling of aryl halides with aryl boronic acids. A simple catalytic system based on Pd(OAc)2/2a was developed, which efficiently catalyses the Suzuki–Miyaura reaction of aryl halides and aryl boronic acids and provides moderate to excellent yields of the corresponding cross-coupling products. Full article
(This article belongs to the Special Issue Palladium-Catalyzed Reactions)
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