New Advances in Chemoenzymatic Synthesis, 2nd Edition

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 1319

Special Issue Editors


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Guest Editor
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, I-27100 Pavia, Italy
Interests: chemoenzymatic synthesis; medicinal chemistry; biocatalysis; protein engineering
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemistry, University of Milan, Via Golgi 19, Milan, Italy
Interests: organic chemistry; chemoenzymatic synthesis; natural product chemistry; food chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of the previous Special Issue “New Advances in Chemoenzymatic Synthesis”.

Chemoenzymatic strategies for the synthesis of complex molecules have recently enriched the field of organic chemistry.

Currently, various examples of the development of chemoenzymatic processes have been described, which have successfully replaced existing chemical processes thanks to the integrated approach of biocatalysis and traditional chemical synthesis. Biocatalysis has been used for laboratory-scale and industrial production in order to obtain synthetic pathways characterized by fewer steps, less waste and efficient global synthesis in terms of yields, regio- and stereoselectivity, process robustness and safety. Under this paradigm, enzyme-catalyzed reactions and the flexibility of chemical derivatization are powerful tools for streamlining access to relevant bioactive molecules.

This Special Issue covers all aspects of the current applications of chemoenzymatic routes in the synthesis of organic compounds (pharmaceuticals, fine chemicals, food additives, flavors, fragrances) at both the laboratory and industrial scales.

Dr. Teodora Bavaro
Prof. Dr. Giovanna Speranza
Guest Editors

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Keywords

  • chemoenzymatic processes
  • biocatalysis
  • organic synthesis
  • biologically active compounds

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Published Papers (1 paper)

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Research

11 pages, 3429 KiB  
Article
Study of Chiral Center Effect on CaLB-Catalyzed Hydrolysis of (±)-1-(Acetoxymethyl)-3, 4, 5-methylpyrrolidin-2-ones
by Luis G. Hernández-Vázquez, Grecia Katherine Sánchez-Muñoz and Jaime Escalante
Catalysts 2024, 14(12), 861; https://doi.org/10.3390/catal14120861 - 26 Nov 2024
Viewed by 688
Abstract
Several chemical and biocatalytic methods have been described for chiral γ-lactams syntheses. However, only one biocatalytic method has been reported for γ4-lactam resolution, while γ2- and γ3-lactams have not been reported. On the other hand, its resolution [...] Read more.
Several chemical and biocatalytic methods have been described for chiral γ-lactams syntheses. However, only one biocatalytic method has been reported for γ4-lactam resolution, while γ2- and γ3-lactams have not been reported. On the other hand, its resolution through biocatalysts is complicated since enzymes such as ENZA-1 (Rhodococcus equi NCIB 40213) and ENZA-20 (Pseudomonas solanacearum NCIB 40249) are difficult to obtain. Therefore, in this paper, the resolution of γ-lactams 7-9 was carried out through a hydrolysis reaction using the commercially available enzyme CaLB. Full article
(This article belongs to the Special Issue New Advances in Chemoenzymatic Synthesis, 2nd Edition)
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