Stability Optimization of Biocatalysts (Enzymes)
A Special Issue of Catalysts (ISSN 2073-4344) belonging to the section "Biocatalysis".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 787
Editor
Interests: discovery of small molecules; anti-tumor drugs targeting kinase; UPS; associated mechanisms
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Special Issue Information
Dear Colleagues,
Enzymes excel in activity, selectivity, and green credentials, yet their industrial footprint is often limited by their modest operational stability; thermal fluctuations, extreme pH, organic co-solvents, mechanical shear, and product inhibition can rapidly erode catalytic performance, driving up process costs. Recent breakthroughs in protein engineering, immobilization chemistry, formulation science, and in silico design now offer unprecedented opportunities to lock in native structures and functions under harsh reaction conditions.
In this Special Issue, we will collect experimental and computational advances that extend the enzyme lifetime while preserving catalytic efficiency. We welcome the submission of original articles, short communications, and reviews on the following topics:
- Directed evolution, rational design, and machine-learning-guided mutagenesis for enhanced rigidity and solvent tolerance.
- Novel immobilization matrices (metal–organic frameworks, hierarchical silica, magnetic nanoparticles, bio-based gels) and cross-linking strategies (CLEAs, CLECs, enzyme nanogels).
- Post-translational modifications, chemical glycosylation, and ionic liquid or deep eutectic solvent formulations.
- Continuous-flow and solid-state biocatalysis, minimizing shear deactivation and facilitating catalyst recycling.
- High-throughput stability assays, in situ spectroscopy, and molecular dynamics insights correlating dynamics with deactivation pathways.
- Techno-economic and life-cycle assessment of stabilized biocatalysts in pharmaceutical, food, and biofuel applications.
By bridging fundamental protein science with process engineering, in this Special Issue, we aim to define practical routes toward achieving robust, reusable enzymatic systems for sustainable manufacturing
Prof. Dr. Feng Wang
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- enzyme stability
- directed evolution
- immobilization
- CLEA
- continuous-flow biocatalysis
- protein engineering
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