Dear Colleagues,

A major challenge in the clinical management of breast cancer is the accurate prognostication of clinical outcome and reliable prediction of which subgroups of patients will benefit (or not) from systemic treatment. Basic discoveries in cancer biology have identified key signaling pathways that drive malignant progression in breast cancer, and panels of bio-markers that assess their activation.  Recently, gene expression profiling has led to the discovery of molecular biomarker sets that define breast cancer subtypes which are associated with different prognoses and are correlated with previously identified clinical bio-markers.  In addition, distinct molecularly defined classes of tumor stroma have been associated with tumor subtypes, and have been found to enhance prognostic power. Mutational analysis and micro-RNA profiling also provide new dimensions for prognosis and prediction of treatment response. Through this special issue of Cancers dedicated towards breast cancer pathology and biomarkers, we are pleased to accept manuscripts for publication which will move us forward in our collective goal of providing optimal, personalized medical care for patients with breast cancer.

Prof. Dr. Sandip Kumar SenGupta
Guest Editor

• breast pathology
• immunohistochemistry
• predictive markers
• prognostic markers
• breast cancer
• personalized medicine
• micro RNA
• signaling pathways
• gene expression profiling