Applications of Single-Cell Genomics in Cancer Research
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 224
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue is dedicated to exploring the groundbreaking applications of single-cell genomics in cancer research. Single-cell genomics has revolutionized our ability to dissect the complex and heterogeneous nature of cancer at an unprecedented resolution. By enabling the analysis of genetic, epigenetic, and transcriptomic variations at the single-cell level, this technology offers profound insights into tumor heterogeneity, clonal evolution, and the intricate tumor microenvironment.
Traditional bulk sequencing methods obscure the diversity of cellular states, whereas single-cell approaches reveal the intricate mosaic of cancer cell populations and their interactions with surrounding stromal and immune cells. Complementing these insights, spatial transcriptomics further enhances our understanding by preserving the spatial context of gene expression within tissue sections, thereby elucidating the spatial organization and interactions of different cell types within the tumor microenvironment. The integration of advanced bioinformatics analyses and tools based on artificial intelligence (AI) is crucial in managing and interpreting the vast datasets that are generated, enabling the identification of complex patterns and novel insights. This Special Issue will present cutting-edge research employing single-cell and spatial multi-omics analysis to uncover the mechanisms of metastasis, therapeutic resistance, and immune evasion.
Through these studies, we will highlight the potential of single-cell and spatial genomics, combined with AI-driven bioinformatics, to identify novel biomarkers and therapeutic targets, paving the way to personalized and more effective cancer treatments. We invite readers to delve into contributions that collectively underscore the transformative impact of these technologies on cancer biology and their promising future in clinical applications.
For this Special Issue, submissions of original research articles and reviews are welcome.
We look forward to receiving your contributions.
Dr. Clelia Peano
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- single-cell genomics
- spatial transcriptomics
- spatial multi-omics analysis
- gene expression
- tumor microenvironment
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