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23 October 2025
Cancers | Highly Viewed Papers and Hot Topic Special Issues on Tumor Microenvironment


We are delighted to share a collection of highly viewed papers in tumor microenvironment that were published in Cancers (ISSN: 2072-6694) in the first half of 2025. In addition, some Special Issues on this topic are currently open for submission. The following is a list of articles and Special Issues that we believe may be of interest to you:

The list of relevant papers can be seen below:

Richness for Tumor-Infiltrating B-Cells in the Oral Cancer Tumor Microenvironment Is a Prognostic Factor in Early-Stage Disease and Improves Outcome in Advanced-Stage Disease
by Irene H. Nauta, Dennis N. L. M. Nijenhuis, Sonja H. Ganzevles, Pamela I. Raaff, Jan Kloosterman, Elisabeth Bloemena, Ruud H. Brakenhoff, C. René Leemans and Rieneke van de Ven
Cancers 2025, 17(1), 113; https://doi.org/10.3390/cancers17010113
Available online: https://www.mdpi.com/2072-6694/17/1/113

“A Novel In Vitro Model of the Bone Marrow Microenvironment in Acute Myeloid Leukemia Identifies CD44 and Focal Adhesion Kinase as Therapeutic Targets to Reverse Cell Adhesion-Mediated Drug Resistance”
by Eleni E. Ladikou, Kim Sharp, Fabio A. Simoes, John R. Jones, Thomas Burley, Lauren Stott, Aimilia Vareli, Emma Kennedy, Sophie Vause and Timothy Chevassut et al.
Cancers 2025, 17(1), 135; https://doi.org/10.3390/cancers17010135
Available online: https://www.mdpi.com/2072-6694/17/1/135

“Metabolic Signaling in the Tumor Microenvironment”
by Ryan Clay, Kunyang Li and Lingtao Jin
Cancers 2025, 17(1), 155; https://doi.org/10.3390/cancers17010155
Available online: https://www.mdpi.com/2072-6694/17/1/155

“SSTR2-Targeted Theranostics in Hepatocellular Carcinoma”
by Majid Momeny, Solmaz AghaAmiri, Servando Hernandez Vargas, Belkacem Acidi, Sukhen C. Ghosh, Tyler M. Bateman, Jack T. Adams, Vahid Khalaj, Ahmed O. Kaseb, Hop S. Tran Cao et al.
Cancers 2025, 17(2), 162; https://doi.org/10.3390/cancers17020162
Available online: https://www.mdpi.com/2072-6694/17/2/162

“Differential Response to Local Stimulator of Interferon Genes Agonist Administration in Tumors with Various Stimulator of Interferon Genes Statuses”
by Alina Drzyzga, Justyna Czapla, Sybilla Matuszczak, Barbara Łasut-Szyszka, Tomasz Cichoń, Ewelina Pilny, Magdalena Jarosz-Biej and Ryszard Smolarczyk
Cancers 2025, 17(2), 175; https://doi.org/10.3390/cancers17020175
Available online: https://www.mdpi.com/2072-6694/17/2/175

“A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches”
by Mina Iskandar, Miguel Xiao Barbero, Muhamed Jaber, Roy Chen, Romulo Gomez-Guevara, Edwin Cruz and Sandy Westerheide
Cancers 2025, 17(2), 257; https://doi.org/10.3390/cancers17020257
Available online: https://www.mdpi.com/2072-6694/17/2/257

Special Issues

Tumor Microenvironment: Cellular Dynamics, Molecular Players, and Mechanisms of Therapy Resistance
Guest Editors: Dr. Teresa Gagliano, Dr. Angeliki Ditsiou and Dr. Viviana Vella
Submission deadline: 31 December 2026

Tumor Suppressor and Targeted Therapy in Hepatocellular Carcinoma: From Diagnosis to Treatment (2nd Edition)
Guest Editors: Prof. Dr. Ching-Sheng Hsu, Dr. Po-Heng Chuang and Dr. I-Cheng Lee
Submission deadline: 30 August 2026

Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy
Guest Editor: Dr. Soumen Saha
Submission deadline: 30 September 2026

The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition
Guest Editor: Dr. Roberto Tamma
Submission deadline: 31 October 2026

You can view and submit relevant papers to Cancers via the following link:
https://www.mdpi.com/journal/cancers

Cancers Editorial Office

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