Ferroptosis in Epilepsy: From Molecular Mechanisms to Possible Therapeutic Alternatives
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 72
Special Issue Editors
Interests: ABC-transporters; refractory epilepsy; hypoxia; pharmacoresistance
Special Issue Information
Dear Colleagues,
Ferroptosis, a type of cell death in which excess reactive oxygen species are catalyzed by iron, has recently emerged as a consequence of epileptic seizures. However, the molecular mechanisms through which seizures lead to ferroptosis have not been fully established. In this context, imbalances in the NRF transcription factor pathway and the groups of genes under its control appear to be involved in the seizure response. However, interactions with other pathways, such as the response to inflammation and/or hypoxia, have not yet been established. On the other hand, the physiological response to epileptic seizures may promote imbalances in iron metabolism, thereby triggering ferroptosis in the central nervous system. This interaction with peripheral organs and systems has been poorly investigated and could represent a pivotal axis on which therapeutic strategies to control ferroptosis levels in the brain parenchyma could work. One piece of physiological evidence of the ferroptosis process is the formation of hemosiderin, an insoluble iron precipitate, which has been clinically linked to the occurrence of epileptic seizures. The surgical removal of hemosiderin in cavernoma surgery is necessary to achieve complete seizure control.
Our aim for this Special Issue is to generate a transversal axis of evidence that connects the molecular mechanisms that determine the process of ferroptosis, its interaction with other molecular pathways involved in epilepsy, and its relationship with other physiological systems to possible new strategies for the control of epileptic seizures, especially those that are drug-resistant.
Prof. Dr. Alberto Lazarowski
Dr. Jerónimo Andrés Auzmendi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epilepsy
- ferroptosis
- hypoxia
- brain parenchyma
- peripheral organs
- iron metabolism
- transferrin
- hemosiderin
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
