The Latest Research on Drug Treatment of Epilepsy
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropharmacology and Neuropathology".
Deadline for manuscript submissions: closed (5 May 2025) | Viewed by 185
Special Issue Editors
Interests: epileptogenesis; seizures; neuroinflammation; aberrant plasticity
Special Issue Information
Dear Colleagues,
Epilepsy, a prevalent neurological disease, affects approximately 50 million people worldwide and is characterized by recurrent seizures due to excessive neuronal excitability and synaptic dysregulation. Current antiseizure medications (ASMs) aim to reduce seizure frequency but often fall short in providing complete control or preventing disease progression. Here, in this Special Issue, we provide the latest research on anti-inflammatory molecules as a potential treatment for seizures and epilepsy.
Recent research highlights that those anti-inflammatory drugs hold promise for epilepsy treatment by targeting neuroinflammation, a key factor in epileptogenesis and seizure progression. Studies indicate that inflammatory responses from neurons, microglia, astrocytes, and blood–brain barrier (BBB) disruptions are associated with seizure onset and the development of chronic epilepsy. Medications that reduce these inflammatory effects may be valuable in modulating the course of epilepsy.
In addition, researchers are examining bioinformatics to identify inflammatory pathways and biomarkers specific to epilepsy, which may guide the development of targeted therapies. Potential anti-inflammatory therapies aim to prevent neuroinflammatory damage, reducing seizure susceptibility, and possibly preventing epilepsy in at-risk individuals, especially those with risk factors such as head trauma or genetic predispositions.
Ongoing studies also explore other drugs targeting and molecule determinants such as cytokines, chemokines, and endocannabinoid pathways, which are integral to the inflammatory cascade associated with epilepsy. Although more clinical trials are necessary, these drugs could significantly alter treatment approaches for epilepsy, especially in cases that do not respond well to traditional anti-seizure medications.
Dr. Alberto E. Musto
Dr. Luis Pacheco
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epilepsy
- neuroinflammation
- seizures
- cannabinoid
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
