The Latest Research on Drug Treatment of Epilepsy
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropharmacology and Neuropathology".
Deadline for manuscript submissions: 5 May 2025 | Viewed by 177
Special Issue Editors
Interests: epileptogenesis; seizures; neuroinflammation; aberrant plasticity
Special Issue Information
Dear Colleagues,
Epilepsy, a prevalent neurological disease, affects approximately 50 million people worldwide and is characterized by recurrent seizures due to excessive neuronal excitability and synaptic dysregulation. Current antiseizure medications (ASMs) aim to reduce seizure frequency but often fall short in providing complete control or preventing disease progression. Here, in this Special Issue, we provide the latest research on anti-inflammatory molecules as a potential treatment for seizures and epilepsy.
Recent research highlights that those anti-inflammatory drugs hold promise for epilepsy treatment by targeting neuroinflammation, a key factor in epileptogenesis and seizure progression. Studies indicate that inflammatory responses from neurons, microglia, astrocytes, and blood–brain barrier (BBB) disruptions are associated with seizure onset and the development of chronic epilepsy. Medications that reduce these inflammatory effects may be valuable in modulating the course of epilepsy.
In addition, researchers are examining bioinformatics to identify inflammatory pathways and biomarkers specific to epilepsy, which may guide the development of targeted therapies. Potential anti-inflammatory therapies aim to prevent neuroinflammatory damage, reducing seizure susceptibility, and possibly preventing epilepsy in at-risk individuals, especially those with risk factors such as head trauma or genetic predispositions.
Ongoing studies also explore other drugs targeting and molecule determinants such as cytokines, chemokines, and endocannabinoid pathways, which are integral to the inflammatory cascade associated with epilepsy. Although more clinical trials are necessary, these drugs could significantly alter treatment approaches for epilepsy, especially in cases that do not respond well to traditional anti-seizure medications.
Dr. Alberto E. Musto
Dr. Luis Pacheco
Guest Editors
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Keywords
- epilepsy
- neuroinflammation
- seizures
- cannabinoid
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