New Insights into Mental Health Research for Neurological and Psychiatric Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropsychiatry".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 452

Special Issue Editors


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Guest Editor
IRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, Italy
Interests: disorders of consciousness and clinical neuropsychology; mental health and well-being in neurological conditions; neurological rehabilitation and innovative therapeutic interventions; chronic pain and pain management; neurodegenerative and neurological disorders; digital and innovative technologies in neuropsychiatry; public health and care models

E-Mail Website
Guest Editor
IRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, Italy
Interests: neuroimaging and biomarkers in neurological disorders; structural and functional MRI (VBM, fMRI); statistical modeling and data analysis in neuroscience; consciousness disorders and neuroimaging correlates; advanced quantitative methods; machine learning in neuroimaging
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Special Issue Information

Dear Colleagues,

In recent decades, there has been growing recognition of the complex and often overlapping relationship between mental and neurological disorders. Conditions such as depression, psychosis, epilepsy, Parkinson’s disease, multiple sclerosis, and dementia frequently co-occur or share common neurobiological mechanisms, underscoring the need for integrated approaches in both research and clinical practice. Mental health, once considered secondary in the management of neurological diseases, is now acknowledged as a central component of overall brain health.

This Special Issue aims to highlight cutting-edge research at the intersection of psychiatry, neurology, and psychology, promoting a multidisciplinary understanding of how mental health is affected in individuals with neurological conditions. We seek contributions that explore innovative strategies for diagnosis, treatment, prevention, and rehabilitation, as well as studies that examine digital tools, predictive models, and personalized care pathways.

We welcome original research articles, systematic reviews, case studies, and methodological papers that advance knowledge in this crucial area. Topics of interest include psychiatric symptoms in neurological disorders, cognitive–behavioral interventions, mental health disparities, and the use of AI or neuroimaging in dual-diagnosis populations. By bringing together diverse perspectives, this Special Issue aims to foster new insights and drive progress in the care of patients living with both mental and neurological conditions.

Dr. Francesco Corallo
Dr. Lilla Bonanno
Guest Editors

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Keywords

  • neuropsychiatric disorders
  • mental health
  • neurological conditions
  • comorbidity
  • integrated care
  • interventions
  • digital health
  • neuroimaging
  • artificial intelligence
  • personalized medicine

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Published Papers (1 paper)

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Research

11 pages, 724 KB  
Article
Sexually Dimorphic Association of Catechol-O-Methyltransferase (COMT) Functional Polymorphism with Dimensional Personality Pathology: A Preliminary Study
by John T. Rucker, Bishal Lamichhane, William B. Haren, Benjamin L. Weinstein and Alok Madan
Brain Sci. 2025, 15(12), 1337; https://doi.org/10.3390/brainsci15121337 - 16 Dec 2025
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Abstract
Objective: Genetic and environmental factors influence the expression of personality pathology and subsequent treatment efforts. This study associates genetics with a contemporary nosology of personality pathology represented in the Alternative Model for Personality Disorders (AMPD). We hypothesized traits from Criterion B of the [...] Read more.
Objective: Genetic and environmental factors influence the expression of personality pathology and subsequent treatment efforts. This study associates genetics with a contemporary nosology of personality pathology represented in the Alternative Model for Personality Disorders (AMPD). We hypothesized traits from Criterion B of the AMPD would differ between genotypes of the catechol-O-methyltransferase (COMT) polymorphism (rs4680/Val158Met variation), given this genetic marker’s role in the metabolism of dopamine and norepinephrine, especially in the prefrontal cortex. Methods: The Personality Inventory for DSM-V (PID-5) was used to quantify personality traits, and the Genomind platform was used to identify the genotypes of the Val158Met COMT polymorphism in 84 psychiatric outpatients. Results: One of the five Criterion B personality domains and three of the twenty-five traits were significantly different among genotypes. Met/Met carriers had significantly higher pathological scores on the broad domain of negative affect and specific traits of perceptual dysregulation and separation insecurity, while the Val/Val carriers had significantly higher scores on the restricted affectivity trait. The COMT Val158Met polymorphism’s association with personality pathology was sexually dimorphic, with the two domains and nine traits significantly different across genotypes in males, but no differences were found in females. A substantial improvement in the regression of domains/traits score when gene–sex interactions were included further confirmed the dimorphism, e.g., the R-squared (adjusted) for the psychoticism improved from 0.03 (p = 0.15) to 0.19 (p < 0.001). Conclusions: Findings offer preliminary support for a link, potentially dimorphic across sexes, between the COMT Val158Met polymorphism and personality pathology as represented by the AMPD. Full article
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