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Biosensors
Special Issues
Aptamer-Based Nanosensing Strategy and Applications
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Aptamer-Based Nanosensing Strategy and Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 992

Special Issue Editors

Dr. Li Gao

E-Mail Website
Guest Editor
School of Life Sciences, Jiangsu University, Zhenjiang 212013, China
Interests: sensors; aptamer; biosensors; detection of various substances using different materials; biochips; protein chips; gene chips
Special Issues, Collections and Topics in MDPI journals
Dr. Jingjie Cui

E-Mail Website
Guest Editor
School of Automation, Hangzhou Dianzi University, Hangzhou 310018, China
Interests: electrochemical sensors; TiO2 nanobelt; highly sensitive detection

Special Issue Information

Dear Colleagues,

An aptamer is a functional single-stranded RNA or DNA, selected by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX); they bind to the target molecule with high affinity. Up until now, various aptamer sensors with unique recognition capabilities have attracted attention from researchers and have been designed for detection purposes. In recent years, aptamer-based nanosensing technologies have emerged as a powerful tool for the detection of biomolecules, pathogens, and environmental pollutants. Their versatility, ease of synthesis, and stability make them ideal candidates for integration with nanomaterials, leading to the development of sensitive and reliable nanosensors.

This Special Issue aims to highlight the latest advancements in aptamer-based nanosensing strategies and their diverse applications in biomedical diagnostics, environmental monitoring, and food safety. We invite original research articles, reviews, and perspectives that explore innovative methodologies, novel nanosensing platforms, and practical applications of aptamer-based sensing technologies. The content covers, but is not limited to, the following:

  1. Aptamer Development Technologies: methods for aptamer selection and engineering, including SELEX and post-selection modifications.
  2. Nanosensor Design: integration of aptamers with functional nanomaterials (e.g., nanoparticles and graphene) to enhance sensing performance.
  3. Sensing Mechanisms: mechanistic insights into aptamer–target interactions and signal transduction methods.
  4. Applications: real-world applications of aptamer-based nanosensors in biomedical diagnostics, environmental monitoring, food safety, and beyond.
  5. Challenges and Future Directions: discussion of current challenges in the field and exploration of emerging trends and future research directions

Dr. Li Gao
Dr. Jingjie Cui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aptamers
  • aptasensor
  • biosensor
  • nucleic acid
  • nucleic acid probe
  • DNA/RNA
  • DNA nanostructure

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Published Papers (2 papers)

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Research

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11 pages, 2267 KiB  
Article
A Label-Free Aptasensor for the Detection of Sulfaquinoxaline Using AuNPs and Aptamer in Water Environment
by Zhaoyang Zhou, Xingyue Chen, Shuang Jiang, Zhuoer Chen, Sixian Wang, Yueyang Ren, Xiaodong Fan and Tao Le
Biosensors 2025, 15(1), 30; https://doi.org/10.3390/bios15010030 - 8 Jan 2025
Viewed by 780
Abstract
Sulfaquinoxaline (SQX) is widely utilized in aquaculture and animal husbandry due to its broad antimicrobial spectrum and low cost. However, it is difficult to degrade, and there are relevant residues in the aquatic environment, which could be harmful to both the ecological environment [...] Read more.
Sulfaquinoxaline (SQX) is widely utilized in aquaculture and animal husbandry due to its broad antimicrobial spectrum and low cost. However, it is difficult to degrade, and there are relevant residues in the aquatic environment, which could be harmful to both the ecological environment and human health. As a new recognition molecule, the aptamer can be recognized with SQX with high affinity and specificity, and the aptamer is no longer adsorbed to AuNPs after binding to SQX, which weakens the catalytic effect of AuNPs. Consequently, an aptasensor for the detection of SQX was successfully developed. This aptasensor exhibits a linear range of 40–640 ng/mL, with a detection limit of 36.95 ng/mL, demonstrating both sensitivity and selectivity. The recoveries of this aptasensor in water samples ranged from 90 to 109.9%, which was quite in line with high-performance liquid chromatography. These findings suggest that the aptasensor is a valuable tool for detecting SQX in aqueous environmental samples. Full article
(This article belongs to the Special Issue Aptamer-Based Nanosensing Strategy and Applications)
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Review

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17 pages, 824 KiB  
Review
DNA Sensors for the Detection of Mercury Ions
by Feng Li, Jinxin Lin, Eric Lichtfouse, Haifeng Qi, Lang Peng, Yangyang Yu and Li Gao
Biosensors 2025, 15(5), 275; https://doi.org/10.3390/bios15050275 - 29 Apr 2025
Abstract
Ecosystem pollution by mercury ions (Hg2+) is a major health concern, yet classical analytical methods for mercury analysis are limited. This paper reviews the advances in Hg2+ detection using DNA as recognition elements in the sensors. DNA as a recognition [...] Read more.
Ecosystem pollution by mercury ions (Hg2+) is a major health concern, yet classical analytical methods for mercury analysis are limited. This paper reviews the advances in Hg2+ detection using DNA as recognition elements in the sensors. DNA as a recognition molecule is inexpensive, simple, and appropriate for real-time detection of Hg2+. This paper discusses the DNA-based sensors that were used for the detection of Hg2+. These can be carried out by electrochemistry, field effect transistors (FET), Raman spectroscopy, colorimetry, and fluorescence resonance energy transfer (FRET). The detection principles and the advantages of DNA in these sensors are also revealed. Finally, the paper provides an overview of prospects and potential challenges in the field. Full article
(This article belongs to the Special Issue Aptamer-Based Nanosensing Strategy and Applications)
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