Special Issue "Advances in Lab-on-Chip Devices II"

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Domenico Caputo

Department of Information Engineering, Electronics and Telecommunications, University of Rome “La Sapienza”, via Eudossiana, 1800184 Rome, Italy
Website | E-Mail
Phone: +39-(0)-6-4458-5832
Fax: +39-(0)-6-4458-5918
Interests: thin film devices; lab-on-chip, photosensors; amorphous silicon; thin film materials, solar cells; electronics for lab-on-chip systems and biomedical engineering

Special Issue Information

Dear Colleagues,

This Special Sssue will be dedicated to the advances in lab-on-chip system.

Topics of the issue are focused on:

Novel materials and/or technologies for lab-on-chip development;

Design and fabrication of microfluidic networks;

Thin film electronic devices (based on organic and inorganic materials) for treatment and detection of biomolecules;

Label-free and labeled detection;

Novel surface functionalization for microfluidic systems;

Recognition methods based on antibodies, aptamers, quantum dots, graphene and nanoparticles;

Applications regarding agro-food analysis, forensic science, health care and diagnostics.

Prof. Domenico Caputo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-chip
  • microfluidic networks
  • surface chemistry treatments
  • thin film devices
  • label-free and labeled detection
  • biomolecular recognition

Published Papers (1 paper)

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Review

Open AccessReview Dielectrophoresis Manipulation: Versatile Lateral and Vertical Mechanisms
Biosensors 2019, 9(1), 30; https://doi.org/10.3390/bios9010030
Received: 24 December 2018 / Revised: 24 January 2019 / Accepted: 30 January 2019 / Published: 26 February 2019
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Abstract
Discussing the topic of the capability of dielectrophoresis (DEP) devices in terms of the selective detection and rapid manipulation of particles based on the DEP force (FDEP) via contactless methods is challenging in medical research, drug discovery and delivery. Nonetheless, the [...] Read more.
Discussing the topic of the capability of dielectrophoresis (DEP) devices in terms of the selective detection and rapid manipulation of particles based on the DEP force (FDEP) via contactless methods is challenging in medical research, drug discovery and delivery. Nonetheless, the process of the selective detection and rapid manipulation of particles via contactless DEP based on dielectric particles and the surrounding medium can reduce the effects of major issues, including physical contact with the particles and medium contamination to overcome operational difficulties. In this review, DEP microelectromechanical system (MEMS) microelectrodes with a tapered profile for the selective detection and rapid manipulation of particles were studied and compared with those of conventional designs with a straight-cut profile. The main objective of this manuscript is to review the versatile mechanism of tapered DEP MEMS microelectrodes for the purpose of selective detection and rapid manipulation. Thus, this review provides a versatile filtration mechanism with the potential for a glomerular-based membrane in an artificial kidneys’ development solution for implementing engineered particles and cells by lateral attraction as well as vertical repulsion in the development of lab-on-a-chip applications. For tapered DEP MEMS microelectrodes, the scope of this study methodology involved the characterisation of DEP, modelling of the polarisation factor and the dynamic dielectric changes between the particles and medium. Comprehensive discussions are presented on the capability of tapered DEP microelectrodes to drive the selected particles and the simulation, fabrication and testing of the tapered profile. This study revealed an outstanding performance with the capability of producing two regions of high electric field intensity at the bottom and top edges of the side wall of tapered microelectrodes. Observations on particle separation mainly by the lateral attraction force of particles with positive DEP on the y-axis and vertical repulsion force of particles with negative DEP on the z-axis proved an efficient and uniform FDEP produced by tapered electrodes. In conclusion, this study confirmed the reliability and efficiency of the tapered DEP microelectrodes in the process of selective detection and rapid manipulation at a higher efficiency rate than straight-cut microelectrodes, which is significant in DEP technology applications. Full article
(This article belongs to the Special Issue Advances in Lab-on-Chip Devices II)
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