Special Issue "Microfluidic Chips for Life Science and Health Care Applications"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 187

Special Issue Editors

1. State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
2. School of Microelectronics, Shanghai University, Shanghai 201800, China
Interests: single molecule; photonics; plasmonics; IVD devices; nanopore; nanowire; biophysics; biosensor
Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
Interests: microfluidics; micro-/nanofabrication; smart materials; surface modification; biomimetic sensors and systems
Special Issues, Collections and Topics in MDPI journals
1. Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201199, China
2. School of Microelectronics, Shanghai University, Shanghai 201800, China
Interests: microfluidics; organ chips; drug screening
Shanghai Industrial μTechnology Research Institute (SITRI), Shanghai 201800, China
Interests: microfluidics; micro- and nano-fabrication; POCT; biochemistry; gene sequencing

Special Issue Information

Dear Colleagues,

Despite their initial application in electrical circuits, silicon-chip-based technologies, including silicon-based structures and silicon-based materials, have also been widely used as tools for research in life science and health care applications. In recent years, silicon chips have been widely used for both scientific research and clinical applications for the detection and characterization of biological substances.

The unique chemical characteristics and advanced fabrication technologies have made silicon a highly versatile material and realized highly efficient bio-sensing structures. Highly complex structures can be made on silicon chips thanks to the advancement of silicon technologies including etching, doping, film deposition, and surface chemistry. Silicon technology is used for detecting, sensing, and manipulating biological substances at a molecular, subcellular, cellular, tissue, and organ level. Silicon-based sensors can be used to detect and transduce chemical, electrical, and photonic signals in various applications, both in vitro and in vivo. The straightforward surface chemistry allows tethering of various molecules, including enzymes and antibodies, to the silicon surface for bio-sensing. However, silicon has its own drawbacks. For example, silicon is more expensive compared to polymers. In addition, the mechanical stiffness of silicon limits the application of direct implanting silicon chips to organisms. The area of silicon-based bio-sensing is still rapidly growing.

In this Special Issue, we welcome all contributions in this area using silicon-chip-based technology for life science and health care applications. We aim to gather original papers, reviews, and perspectives regarding recent advances in structural design, silicon fabrication technologies, surface modification, and novel applications in life science and health care applications, such as point-of-care diagnostics, biomolecule detection, single-molecule analysis, sequencing, imaging, cell manipulation, drug delivery, and tissue engineering.

You are invited to participate in this project. If you would be interested in submitting a contribution, or if you have any questions, please feel free to contact us.

Prof. Dr. Chang Chen
Dr. Kaihuan Zhang
Prof. Dr. Qing Chang
Dr. Ruihua Ding
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • multi-electrode silicon chip
  • field effect transistors
  • lab on chip
  • surface chemistry for silicon
  • silicon photonics
  • bio-imaging on chip
  • trace detection
  • gene sequencing
  • cell culture and sorting

Published Papers

This special issue is now open for submission.
Back to TopTop