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Biosensors
Special Issues
Advanced Biosensors and Bioelectronics: From Liquid Metal-Based to Flexible Devices
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Advanced Biosensors and Bioelectronics: From Liquid Metal-Based to Flexible Devices

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 3453

Special Issue Editors

Dr. Rui Guo

E-Mail Website
Guest Editor
Laboratory of Biomedical Flexible Electronics, Department of Biomedical Engineering, Tianjin University, Tianjin, China
Interests: flexible electronic devices based on liquid metals
Special Issues, Collections and Topics in MDPI journals
Dr. Xuyang Sun

E-Mail Website
Guest Editor
School of Engineering Medicine, Beihang University (BUAA), Beijing 100191, China
Interests: liquid metals; biomaterials; flexible electronics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors and bioelectronics play a pivotal role in medical diagnostics, environmental monitoring, and food safety. The unique physical and chemical properties of liquid metals offer new possibilities for the innovation of biosensors, with their high conductivity, malleability, and biocompatibility making them promising candidates for flexible electronics and biomedical applications. This Special Issue invites submissions on the cutting-edge research and applications of liquid metals in the field of biosensing, focusing on the following themes:

  1. Liquid metals as biomedical materials: exploring the synthesis, properties, and biomedical applications of liquid metals, including drug delivery systems, artificial implants, and tissue engineering;
  2. Manufacturing techniques for liquid metal sensors: research on and development of manufacturing processes for liquid metal sensors, covering material selection, device design, processing techniques, and integration methods to enhance sensor performance and reliability;
  3. Prospects of liquid metals in biosensing: analyzing the trends and future applications of liquid metals in biosensing, discussing potential improvements to existing technologies, and proposing new concepts.

We welcome original research papers, review articles, and case reports by researchers, engineers, and clinicians.

Dr. Rui Guo
Dr. Xuyang Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liquid metal
  • biosensors
  • flexible electronics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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15 pages, 3686 KiB  
Article
A Wearable Molecularly Imprinted Electrochemical Sensor for Cortisol Stable Monitoring in Sweat
by Yitao Chen, Zidong He, Yuanzhao Wu, Xinyu Bai, Yuancheng Li, Weiwei Yang, Yiwei Liu and Run-Wei Li
Biosensors 2025, 15(3), 194; https://doi.org/10.3390/bios15030194 - 18 Mar 2025
Viewed by 923
Abstract
Cortisol, a steroid hormone, is closely associated with human mental stress. The rapid, real-time, and continuous detection of cortisol using wearable devices offers a promising approach for individual mental health. These devices must exhibit high sensitivity and long-term stability to ensure reliable performance. [...] Read more.
Cortisol, a steroid hormone, is closely associated with human mental stress. The rapid, real-time, and continuous detection of cortisol using wearable devices offers a promising approach for individual mental health. These devices must exhibit high sensitivity and long-term stability to ensure reliable performance. This study developed a wearable electrochemical sensor based on molecularly imprinted polymer (MIP) technology for real-time and dynamic monitoring of cortisol in sweat. A flexible gold (Au) electrode with interfacial hydrophilic treatment was employed to construct a highly stable electrode. The integration of a silk fibroin/polyvinylidene fluoride (SF/PVDF) composite membrane facilitates directional sweat transport, while liquid metal bonding enhances electrode flexibility and mechanical anti-delamination capability. The sensor exhibits an ultrawide detection range (0.1 pM to 5 μM), high selectivity (over 100-fold against interferents such as glucose and lactic acid), and long-term stability (less than 3.76% signal attenuation over 120 cycles). Additionally, a gradient modulus design was implemented to mitigate mechanical deformation interference under wearable conditions. As a flexible wearable device for cortisol monitoring in human sweat, the sensor’s response closely aligns with the diurnal cortisol rhythm, offering a highly sensitive and interference-resistant wearable solution for mental health monitoring and advancing personalized dynamic assessment of stress-related disorders. Full article
(This article belongs to the Special Issue Advanced Biosensors and Bioelectronics: From Liquid Metal-Based to Flexible Devices)
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Review

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22 pages, 10435 KiB  
Review
Review of Liquid Metal Fiber Based Biosensors and Bioelectronics
by Xiaotong Liu, Hui Xu, Jiameng Li, Yanqing Liu and Haojun Fan
Biosensors 2024, 14(10), 490; https://doi.org/10.3390/bios14100490 - 9 Oct 2024
Cited by 1 | Viewed by 2221
Abstract
Liquid metal, as a novel material, has become ideal for the fabrication of flexible conductive fibers and has shown great potential in the field of biomedical sensing. This paper presents a comprehensive review of the unique properties of liquid metals such as gallium-based [...] Read more.
Liquid metal, as a novel material, has become ideal for the fabrication of flexible conductive fibers and has shown great potential in the field of biomedical sensing. This paper presents a comprehensive review of the unique properties of liquid metals such as gallium-based alloys, including their excellent electrical conductivity, mobility, and biocompatibility. These properties make liquid metals ideal for the fabrication of flexible and malleable biosensors. The article explores common preparation methods for liquid metal conductive fibers, such as internal liquid metal filling, surface printing with liquid metal, and liquid metal coating techniques, and their applications in health monitoring, neural interfaces, and wearable devices. By summarizing and analyzing the current research, this paper aims to reveal the current status and challenges of liquid metal conductive fibers in the field of biosensors and to look forward to their development in the future, which will provide valuable references and insights for researchers in the field of biomedical engineering. Full article
(This article belongs to the Special Issue Advanced Biosensors and Bioelectronics: From Liquid Metal-Based to Flexible Devices)
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