Advances in Nanopores for Protein Sensing

Dear Colleagues,

Proteins are chains of amino acids serving as the building blocks of cells, with important functions including the creation of antibodies and enzymes. There has been a growing demand for a novel sensor that can detect a vast dynamic range of proteins for complete proteome analysis.  In this regard, nanopore technology is considered a promising approach capable of counting proteins at a single-amino-acid level.  Biological nanopores have already proven useful for not only detecting proteins but also sequencing short peptides by ionic current measurements. Solid-state nanopores are also an excellent platform that can be integrated with various nanostructures to extend the single-molecule sensing ability such as surface-enhanced Raman spectroscopy and tunneling current detections.

This Special Issue aims to publish cutting-edge research and reviews on this exciting research area, including, but not limited to, the following topics:

• Biological nanopores for single-protein detection and peptide sequencing;
• Solid-state nanopore sensing for single-protein analyses;
• Integrated nanopore sensors for single-protein detections;
• Post-digital processing and machine learning for analyzing nanopore data of proteins

Dr. Makusu Tsutsui
Dr. Kazumichi Yokota
Guest Editors

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