The Ribosomal DNA: A Key Player in the Cell
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 3032
Special Issue Editor
Interests: DNA topology in difficult-to-replicate genomic regions; DNA replication and transcription; DNA repair of topoisomerase mediated DNA damage; genomic instability
Special Issue Information
Dear Colleagues,
Ribosomal DNA (rDNA) gives rise to ribosomal RNA, which constitutes an essential part of ribosomes, the platform for all protein synthesis in the cell. In eukaryotes, rDNA consists of many repeats, which form clusters in the genome. Five clusters exist in human cells whereas only one is found in budding yeast, S cerevisiae. Despite the difference in the overall organization, the repeats contain similar elements in all eukaryotes. Thus, the conserved ribosomal RNA genes are separated by less-conserved intergenic spacer regions holding an origin of replication, an element causing replication fork blockage and promoters for non-coding transcripts. A highly complex interplay occurs between all these elements to ensure the high production of ribosomal RNA, genomic stability, and rDNA copy number maintenance.
This Special Issue of Biomolecules will cover new advances in this highly complex interplay as well as highlight the implications of these for genomic stability in general, cancer, and aging.
Prof. Dr. Anni Hangaard Andersen
Guest Editor
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Keywords
- rDNA transcription
- R-loop formation
- rDNA replication
- fork blockage
- silencing
- repeat stability
- copy number maintenance
- rDNA repair
- genome instability
- aging
- cancer
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