Novel Pathways and Sites of Fructose Metabolism

Dear Colleagues,

There is currently high interest in fructose metabolism due to a strong link between its high dietary intake and the development of obesity and associated comorbidities. From a metabolic standpoint, fructose presents an interesting dichotomy being at once a gluconeogenic and lipogenic substrate. Moreover, fructose promotes glucose utilization while at the same time competing with it for the major pathways of carbohydrate disposal and storage. While much attention is currently focused on its promotion of lipid accumulation in the liver, recent studies indicate that fructose can also be metabolized by other mammalian tissues such as the intestine and adipose tissue, as well as by other organisms including microorganisms of the intestinal microbiome. Moreover, although high fructose feeding is strongly linked with dyslipidemia, lipids per se are typically not the principal proximate products of fructose metabolism. This Special Issue will bring together studies of fructose metabolism in novel settings involving tissues and/or organisms with an emphasis on elucidating the principal metabolic products and their relationship with the long-term well-being of the organism.

Dr. John Griffith Jones
Guest Editor

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