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Special Issue "Aptamer-Based Biosensors"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (10 November 2019).
Interests: Ribozymes; RNA-protein interactions; 3D structures of RNA-protein complexes; Aptamers; Aptamer-based biosensors; Molecular beacon aptamers; anti-viral aptamers
Aptamers are isolated from combinatorial libraries of nucleic acids by iterative rounds of selection and an amplification process for binding to a specific ligand. Since the inception of the aptamer selection methodology nearly three decades ago, several high-affinity and specific aptamers were reported against a wide range of targets, including simple ions, small molecules, peptides, proteins, organelles, viruses, and whole cells. Although the aptamers compared with antibodies and even referred as “rivals” to antibodies, the aptamers have several advantages over antibodies such as being smaller in size, easier to synthesize, higher stability, several modifications can be incorporated, no batch-to-batch variations. Previously, several aptamers were compared with antibodies on different bio-sensing platforms for binding to several biomarkers and ligands. These studies revealed that the aptamers displayed superiority in terms of sensitivity and discriminating ability especially towards closely related ligands. Considering these advantages aptamers are rapidly being adopted in various fields which are not only limited to therapeutics, medical diagnosis but also in imaging, food safety, and environmental monitoring.
This Special Issue of Biomolecules is dedicated to aptamer-based sensing platforms for the detection of a wide range of ligand analysis focusing on the new platforms, sensitivity, and rapid analyses. We welcome both original articles and review articles that cover state-of-the-art in this rapidly developing area.
Dr. Penmetcha Kumar
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- RNA-protein interactions
- 3D structures of RNA-protein complexes
- aptamer-based biosensors
- molecular beacon aptamers
- anti-viral aptamers