Perspectives of Prostaglandins

Dear Colleagues,

Prostaglandins are a group of potent biological mediators derived principally from arachidonic acid. They are involved in a wide range of normal physiological activities and pathological conditions, including basic smooth muscle physiology, cellular transformation and differentiation, reproduction, inflammation, resolution of inflammation, and cancer, to name a few. Both prostaglandin synthesis and metabolism are complex, with multiple steps and rate limiting enzymes involved. Additional complexity is added as prostaglandins act via distinct G-protein couple receptors (GPCRs) to activate different downstream signaling pathways. The pharmacological manipulation of the prostaglandin pathway has provided targets for clinical applications but. unfortunately, not always with the hoped-for success.

In this Special Issue of Biomolecules, ‘Perspectives of Prostaglandins’, we would like to incorporate a range of viewpoints from original research articles on basic science model investigations through to clinical applications. The aim of this issue is to present original research articles and critical reviews about key aspects of the prostaglandin pathway from regulation of synthesis and metabolism, through to prostaglandin-initiated GPCR signaling pathways, with a special focus on new insights into the role/regulation of the PG pathway in health and disease.

Dr. Donna M Slater
Guest Editor

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• Prostaglandins
• Prostaglandin metabolites
• Prostaglandin signaling via GPCRs
• Initiation / resolution of inflammation
• Historical perspectives and new discoveries