Animal Models: Exploring the Biological Bases and New Experimental Therapies for Neurodevelopmental Disorders
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 185
Special Issue Editor
Interests: animal models; impulse-control disorders; dopamine; serotonin; neurosteroids; Tourette syndrome; pathological aggression; pathological gambling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodevelopmental disorders (NDDs) comprise a wide array of disabilities, such as attention deficit/hyperactivity disorder (ADHD), autistic spectrum disorder (ASD), communication and learning disorders, tic disorders, and conduct disorder/pathological aggression.
Although the prevalence of NDDs is estimated to affect 15%–20% of the pediatric population, and several indicators point to an increase in their incidence, the neurobiological underpinnings of these disorders remain largely enigmatic. More troubling still, pharmacotherapies for these diseases remain largely unsatisfactory and often target only a marginal subset of symptoms.
Despite these significant challenges, recent years have witnessed a substantial improvement in our understanding of the pathogenesis of NDDs, partly through the generation of animal models that recapitulate genetic and/or environmental susceptibility factors linked to these conditions. These scientific breakthroughs are leading to the development of promising therapeutic avenues for these disorders.
The current Special Issue of Biomolecules is dedicated to spotlighting pioneering directions in the development of novel animal models, theoretical and conceptual frameworks, and putative therapeutic agents for NDDs. The main goal is to showcase how these ongoing directions are expanding our knowledge of the pathophysiology of these conditions and pointing to novel treatments for the management of these disorders.
Dr. Marco Bortolato
Guest Editor
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