Calcium Channel Function and Blockade for Better Neurological Health

Dear Colleagues,

Empirical work on calcium channel blockade more than 50 years ago led to landmark advances in the treatment of cardiovascular diseases. The potential for calcium channel blockade to improve neurological outcomes is only becoming realized very recently. New and emerging frontiers of research include augmentation or adjunctive use of calcium channel blockade for brain health (e.g. in bipolar depression), while genome wide association studies implicate calcium channel encoding regions in psychosis (e.g. CACNA1C). However, the mechanisms underlying calcium channels importance to neurological function are incompletely understood. The objective of this Special Issue, “Calcium Channel Function and Blockade for Better Neurological Health”, is to streamline this field of research and inform novel lines of investigation on the full spectrum of calcium channels (e.g. voltage-gated, ligand-gated) and their subunits, interactions with neurotransmitters, or pharmacological approaches to calcium channel blockade. The special issue will encompass the full scope of research and experimental designs from basic science, genetics, clinical trials, original research, and review papers.

The special issue intends to bring together research with broad application to brain health, including but not limited to stroke, cerebral vasculature, dementia, cognitive function, psychosis, bipolar disorder, depression and anxiety disorders, epilepsy, pain, neuropathy, fibromyalgia, restless legs, and alcohol withdrawal.

Dr. Phillip J. Tully
Ms. Rianne de Heus
Guest Editors

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• calcium channels
• calcium channel agonists
• neurological disorders
• neurology
• brain health