Mass Spectrometry Imaging in Neuroscience
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 5048
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are pleased to announce that a Special Issue of Biomolecules, entitled “Mass Spectrometry Imaging in Neuroscience”, is now open for submission. I would like to invite you to submit some of your recent work or a topical review.
Mass spectrometry imaging (MSI) has become a valuable chemical imaging tool for biological research, offering high chemical specificity, high sensitivity, and multiplexed detection of multiple biomolecules that localize within cells and tissues at cellular and subcellular spatial resolution. MSI can be performed as either a targetting or non-targetting approach, the latter providing a significant analysis tool for exploring new samples without a priori knowledge. Different MSI techniques are suitable for a variety of applications with particular specifications and demands on spatial resolution, detected molecules, sensitivity, and sample status.
Over recent decades, MSI has been increasingly applied to study molecular organization and the functional relations of the underlying biological processes in neuronal cells, the brain, and neurological diseases and disorders. The spatial localization of biomolecules such as lipids, proteins, peptides and metabolites, etc. can now be mapped and related to their neurological functions. Cellular and subcellular molecular turnover, reflecting the synthesis, metablism and degradation in neurons and the brain at a certain stage of neuronal development, maturation, or pathology, is now being added to this knowledge base. Biomarkers distributed within a specific regions of cells and tissues provide valuable insights into cellular pathways of neurodegenerative diseases. These are just a several of the diverse topics that can be investigated using MSI.
We are pleased to invite you to contribute an original article or review focusing on any aspects of neurobiology using MSI.
This SI aims to provide the readership with a comprehensive insight into different MSI technologies along with their specific applications in neurobiology. This will help researchers to identify the potential and suitability of MSI techniques for further applications in the field.
Dr. Nhu Thi Ngoc Phan
Guest Editor
Manuscript Submission Information
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Keywords
- mass spectrometry imaging
- secondary ion mass spectrometry (SIMS)
- matrix-assisted laser desorption/ionization (MALDI)
- desorption electrospray ionization (DESI)
- laser ablation–inductively coupled plasma–mass spectrometry imaging (LA-ICP-MSI)
- multi-isotope imaging mass spectrometry (MIMS)
- molecular and organelle turnover
- brain
- neurons
- synapses
- neuronal stem cells
- membrane lipids
- synaptic proteins
- neural peptides
- metabolites
- diseases
- disorders
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