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Biomimetics
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Biomimetic Scaffolds for Hard Tissue Surgery: 2nd Edition
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Biomimetic Scaffolds for Hard Tissue Surgery: 2nd Edition

A special issue of Biomimetics (ISSN 2313-7673).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 5121

Special Issue Editors

Prof. Dr. Ryszard Uklejewski

E-Mail Website
Guest Editor
Department of Constructional Materials and Biomaterials Materials and Biomaterials, Faculty of Materials Engineering, Kazimierz Wielki University, Bydgoszcz, Poland
Interests: bone tissue biomechanics and endocrinology; orthopaedic biomaterials; connecting scaffolds for resurfacing arthroplasty endoprostheses; surface modification and functionalization of biomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Mariusz Winiecki

E-Mail Website
Guest Editor
Department of Constructional Materials and Biomaterials, Faculty of Materials Engineering, Kazimierz Wielki University, Bydgoszcz, Poland
Interests: orthopaedic biomaterials; engineering of bone–implant interface; scaffolds for bone reconstruction; surface modification and functionalization of biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hard tissues are living, mineralized tissues possessing a high degree of hardness that are found in organs such as bones and teeth (enamel, dentin, and cementum). The ultimate goal of bone and joint surgery, craniofacial surgery, dental surgery, or, in general, hard tissue surgery is reconstruction via the implantation of a device to replace a bone and/or joints affected by disease or traumatic damage or deformity. Reconstruction of critical-sized loss or defects caused by trauma, tumour excision, osteoarthritis, and other bone-resorption-related diseases or disorders remains a significant challenge. However, three-dimensional biomaterial scaffolds have emerged as relatively novel tools used to repair such damaged hard tissues. Biomimetic scaffolds are designed and generated as biomaterial architectures that mimic the regeneration of native tissue. Scaffolds for hard tissue surgery require mechanical stability to support the needed geometry of tissue loss or defects and facilitate bearing external loading. Such scaffolds should provide internal microarchitecture to the tissue that is to be regenerated with an internal, interconnected porous network of effective space for infiltration, growth, and differentiation of bone marrow mesenchymal stem cells, vasculature ingrowth, and new tissue growth, and ensure a channel of material exchange with the external environment (delivering oxygen and other nutrients to the cells and waste removal). Thus, the design of such scaffolds is extremely important to the success of clinical outcomes in hard tissue surgery. The newest trend in this field is the viable bioinspired structural and functional design of tissue-mimicking 3D-printed (composite or hybrid) scaffolds with interconnected pore structures of controlled and often gradual porosity of implants with the synergistic functions of promoting bone regeneration (often seeded with mesenchymal stromal cells and involving biomolecules and growth factors) and reducing local bacterial infections (intrinsically antimicrobial or loaded with antibiotics, peptides, antimicrobial metallic ions, and/or nanoparticles).

This Special Issue aims to exhibit and discuss the latest advancements in biomimetic scaffolds for hard tissue surgery. It is our pleasure to invite you to submit a manuscript to this Special Issue. Full papers, communications, and reviews are all welcome.

Potential topics include, but are not limited to, the following:

  • Biomimetic design strategies for scaffolds;
  • Techniques for fabricating biomimetic scaffolds;
  • Novel biomaterials for biomimetic scaffolds;
  • Biodegradability design of biomimetic scaffolds;
  • Surface functionalization of biomimetic scaffolds;
  • Clinical applications of biomimetic scaffolds.

Prof. Dr. Ryszard Uklejewski
Dr. Mariusz Winiecki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic scaffolds
  • hard tissue surgery
  • hard tissue regeneration
  • bone regeneration
  • biomimetic microstructure and biomechanics, biocompatibility
  • biodegradability design
  • scaffold functionalization

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Related Special Issue

Published Papers (3 papers)

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Research

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12 pages, 7489 KiB  
Article
Apatite Formation on α-Tricalcium Phosphate Modified with Bioresponsive Ceramics in Simulated Body Fluid Containing Alkaline Phosphatase
by Taishi Yokoi, Shinji Tomita, Jin Nakamura, Ayae Sugawara-Narutaki, Yuko Matsukawa, Masakazu Kawashita and Chikara Ohtsuki
Biomimetics 2024, 9(8), 502; https://doi.org/10.3390/biomimetics9080502 - 20 Aug 2024
Viewed by 1034
Abstract
Bioresponsive ceramics, a new concept in ceramic biomaterials, respond to biological molecules or environments, as exemplified by salts composed of calcium ions and phosphate esters (SCPEs). SCPEs have been shown to form apatite in simulated body fluid (SBF) containing alkaline phosphatase (ALP). Thus, [...] Read more.
Bioresponsive ceramics, a new concept in ceramic biomaterials, respond to biological molecules or environments, as exemplified by salts composed of calcium ions and phosphate esters (SCPEs). SCPEs have been shown to form apatite in simulated body fluid (SBF) containing alkaline phosphatase (ALP). Thus, surface modification with SCPEs is expected to improve the apatite-forming ability of a material. In this study, we modified the surface of α-tricalcium phosphate (α-TCP) using methyl, butyl, or dodecyl phosphate to form SCPEs and investigated their apatite formation in SBF and SBF containing ALP. Although apatite did not form on the surface of the unmodified α-TCP in SBF, apatite formation was observed following surface modification with methyl or butyl phosphate. When ALP was present in SBF, apatite formation was especially remarkable on α-TCP modified with butyl phosphate. These SCPEs accelerated apatite formation by releasing calcium ions through dissolution and supplying inorganic phosphate ions, with the latter process only occurring in SBF containing ALP. Notably, no apatite formation occurred on α-TCP modified with dodecyl phosphate, likely because of the low solubility of the resulting calcium dodecyl phosphate/calcium phosphate composites. This new method of using SCPEs is anticipated to contribute to the development of novel ceramic biomaterials. Full article
(This article belongs to the Special Issue Biomimetic Scaffolds for Hard Tissue Surgery: 2nd Edition)
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Review

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20 pages, 2122 KiB  
Review
Integration of Sustainable and Net-Zero Concepts in Shape-Memory Polymer Composites to Enhance Environmental Performance
by Mattew A. Olawumi, Francis T. Omigbodun and Bankole I. Oladapo
Biomimetics 2024, 9(9), 530; https://doi.org/10.3390/biomimetics9090530 - 3 Sep 2024
Cited by 1 | Viewed by 1201
Abstract
This review research aims to enhance the sustainability and functionality of shape-memory polymer composites (SMPCs) by integrating advanced 4D printing technologies and sustainable manufacturing practices. The primary objectives are to reduce environmental impact, improve material efficiency, and expand the design capabilities of SMPCs. [...] Read more.
This review research aims to enhance the sustainability and functionality of shape-memory polymer composites (SMPCs) by integrating advanced 4D printing technologies and sustainable manufacturing practices. The primary objectives are to reduce environmental impact, improve material efficiency, and expand the design capabilities of SMPCs. The methodology involved incorporating recycled materials, bio-based additives, and smart materials into 4D printing processes, and conducting a comprehensive environmental impact and performance metrics analysis. Significant findings include a 30% reduction in material waste, a 25% decrease in energy consumption during production, and a 20% improvement in shape-memory recovery with a margin of error of ±3%. Notably, the study highlights the potential use of these SMPCs as biomimetic structural biomaterials and scaffolds, particularly in tissue engineering and regenerative medicine. The ability of SMPCs to undergo shape transformations in response to external stimuli makes them ideal for creating dynamic scaffolds that mimic the mechanical properties of natural tissues. This increased design flexibility, enabled by 4D printing, opens new avenues for developing complex, adaptive structures that support cell growth and tissue regeneration. In conclusion, the research demonstrates the potential of combining sustainable practices with 4D printing to achieve significant environmental, performance, and biomedical advancements in SMPC manufacturing. Full article
(This article belongs to the Special Issue Biomimetic Scaffolds for Hard Tissue Surgery: 2nd Edition)
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27 pages, 2389 KiB  
Review
Biomimetic Scaffolds of Calcium-Based Materials for Bone Regeneration
by Ki Ha Min, Dong Hyun Kim, Koung Hee Kim, Joo-Hyung Seo and Seung Pil Pack
Biomimetics 2024, 9(9), 511; https://doi.org/10.3390/biomimetics9090511 - 24 Aug 2024
Cited by 1 | Viewed by 2320
Abstract
Calcium-based materials, such as calcium carbonate, calcium phosphate, and calcium silicate, have attracted significant attention in biomedical research, owing to their unique physicochemical properties and versatile applications. The distinctive characteristics of these materials, including their inherent biocompatibility and tunable structures, hold significant promise [...] Read more.
Calcium-based materials, such as calcium carbonate, calcium phosphate, and calcium silicate, have attracted significant attention in biomedical research, owing to their unique physicochemical properties and versatile applications. The distinctive characteristics of these materials, including their inherent biocompatibility and tunable structures, hold significant promise for applications in bone regeneration and tissue engineering. This review explores the biomedical applications of calcium-containing materials, particularly for bone regeneration. Their remarkable biocompatibility, tunable nanostructures, and multifaceted functionalities make them pivotal for advancing regenerative medicine, drug delivery system, and biomimetic scaffold applications. The evolving landscape of biomedical research continues to uncover new possibilities, positioning calcium-based materials as key contributors to the next generation of innovative biomaterial scaffolds. Full article
(This article belongs to the Special Issue Biomimetic Scaffolds for Hard Tissue Surgery: 2nd Edition)
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