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Biomimetics
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Advances in Bioceramics for Bone Regeneration: 2nd Edition
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Advances in Bioceramics for Bone Regeneration: 2nd Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1235

Special Issue Editors

Prof. Dr. Mihai Valentin Predoi

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Guest Editor
Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
Interests: numerical simulation of ultrasound propagation; nondestructive ultrasonic technique for biomaterials; sound propagation simulation; nonlinear vibrations; plate vibrations; vibrations in aeronautical structures; finite element analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Simona Liliana Iconaru

E-Mail Website
Guest Editor
National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania
Interests: biomaterials; biomedical applications; environmental applications; surface analysis; antimicrobial properties
Special Issues, Collections and Topics in MDPI journals
Dr. Carmen Steluta Ciobanu

E-Mail Website
Guest Editor
National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
Interests: biomaterials; nanoparticles; hydroxyapatite; biomedical applications; physico-chemical properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials are materials that are designed to interact with biological systems for either therapeutic or medical diagnostic purposes. Various biomaterials have been developed for use as synthetic bone graft substitutes, ranging from metals to polymers; however, bioceramics remain the most used materials. Furthermore, calcium orthophosphates (CaP), due to their similarity to the mineral phase of bones, are the most widely used. Hydroxyapatite (HAp) is the only CaP that can be obtained both by precipitation in aqueous systems at low temperatures and by reaction in the solid state. HAp represents approximately 65% of the weight of bone tissue, but the properties of bone are not only explained by its composition but also by its complex structure.

In this Special Issue, we aim to bring together interdisciplinary studies focused on research on recent advances in the creation of innovative and functional nanostructured materials that could be used in bone generation.

Prof. Dr. Mihai Valentin Predoi
Dr. Simona Liliana Iconaru
Dr. Carmen Steluta Ciobanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydroxyapatite
  • calcium phosphate
  • biomaterials
  • bioceramics
  • bone regeneration

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Published Papers (2 papers)

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24 pages, 6350 KB  
Article
Composites Derived from Aluminium-Modified Biphasic Calcium-Phosphate for Bone Regeneration
by Raluca Lucacel-Ciceo, Roxana Dudric, Razvan Hirian, Iulia Lupan, Oana Koblicska, Roxana Strimbu, Radu George Hategan, Dorina Simedru and Zorita Diaconeasa
Biomimetics 2025, 10(12), 824; https://doi.org/10.3390/biomimetics10120824 - 9 Dec 2025
Viewed by 336
Abstract
In this research, aluminium-doped biphasic calcium phosphate (Al-BCP) was synthesized by co-precipitation and formulated with hydrolyzed collagen and acetylsalicylic acid (ASA) to yield composites designed as a new class of bone-regenerative biomaterials with enhanced biological performance. Undoped and Al-modified powders (5/10 wt% Al [...] Read more.
In this research, aluminium-doped biphasic calcium phosphate (Al-BCP) was synthesized by co-precipitation and formulated with hydrolyzed collagen and acetylsalicylic acid (ASA) to yield composites designed as a new class of bone-regenerative biomaterials with enhanced biological performance. Undoped and Al-modified powders (5/10 wt% Al precursor) were prepared at 40 °C (pH ~ 11) and calcined at 700 °C, and composites were produced at a 1:1:0.1 mass ratio (ceramic–collagen–ASA). Structure and chemistry were assessed by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) and Raman spectroscopies, and X-ray photoelectron spectroscopy (XPS). Morphology and elemental distribution were examined by scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDX). Biological performance was preliminarily evaluated using HaCaT (immortalized human keratinocytes) viability and antibacterial assays against Staphylococcus aureus and Escherichia coli. XRD confirmed a biphasic hydroxyapatite/β-tricalcium phosphate system and showed that Al incorporation shifted the phase balance toward hydroxyapatite (HAp fraction 54.8% in BCP vs. ~68.6–68.7% in Al-doped samples). FTIR/Raman preserved BCP vibrational signatures and revealed collagen/ASA bands in the composites. XPS/EDX verified the expected composition, including surface N 1s from organics and Al at ~2–5 at% for doped samples, with surface Ca/P ≈ 1.15–1.16. SEM revealed multigranular microstructures with homogeneous Al distribution. All composites were non-cytotoxic (≥70% viability); M_Al10_Col_ASA exceeded 90% viability at 12.5% dilution. Preliminary antibacterial assays against Gram-positive and Gram-negative strains showed modest, time-dependent reductions in CFU relative to controls. These results corroborate the compositional/structural profile and preliminary biological performance of Al-BCP–collagen–ASA composites as multifunctional bone tissue engineering materials that foster a bone-friendly microenvironment, warranting further evaluation for bone regeneration. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration: 2nd Edition)
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17 pages, 6668 KB  
Article
Fabrication and Characterization of Semi-Resorbable Bioactive Membrane Derived from Silk Fiber Sheet for Guided Bone Regeneration
by Kanokporn Santavalimp, Jirut Meesane, Juthakarn Thonglam, Kawintip Prasongyuenyong and Prisana Pripatnanont
Biomimetics 2025, 10(11), 790; https://doi.org/10.3390/biomimetics10110790 - 20 Nov 2025
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Abstract
The barrier membrane is a key component in guided bone regeneration (GBR); however, there is no current commercially available membrane universally suitable for all clinical situations. The semi-resorbable bioactive barrier membrane derived from a silk fiber sheet (SF), polyvinyl alcohol (PVA), and biphasic [...] Read more.
The barrier membrane is a key component in guided bone regeneration (GBR); however, there is no current commercially available membrane universally suitable for all clinical situations. The semi-resorbable bioactive barrier membrane derived from a silk fiber sheet (SF), polyvinyl alcohol (PVA), and biphasic calcium phosphate (BCP) was fabricated to provide improved physical, mechanical, and bioactive properties. There were four experimental groups: PVA/SF, 1BCP/PVA/SF, 3BCP/PVA/SF, and 5BCP/PVA/SF. All fabricated membranes appeared white in color with a smooth texture; however, SEM images revealed a rougher top surface compared to the bottom surface. FTIR and DSC validated the presence of the SF and PVA with or without BCP. All membranes displayed high hydrophilicity, except the PVA/SF group, which remained hydrophobic on the bottom surface. The water uptake of all groups reached the plateau phase within 10 min. The degradation rate fell within the range of 5–20% over a three-month period. Both fibroblastic and osteoblastic cells attached and survived on the BCP-incorporated membranes, comparable to those observed in the commercially available ossifying collagen membrane. Among the fabricated membranes, the 3BCP/PVA/SF formulation demonstrated the most favorable physical, mechanical, and biological properties for GBR applications. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration: 2nd Edition)
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