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Biomedicines
Special Issues
Erectile Dysfunction and Cardiovascular Disease
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Erectile Dysfunction and Cardiovascular Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6024

Special Issue Editor

Dr. Giuseppe Massimo Sangiorgi

E-Mail Website
Guest Editor
Department of Biomedicine and Prevention, University of Rome Tor Vergata - Cardiac Cath Lab, Rome, Italy
Interests: atherosclerosis; coronary intervention; peripheral intervention; erectile dysfunction

Special Issue Information

Dear Colleagues,

Sexuality is a marker of human health. Every disturbance of the sexual sphere, including erectile dysfunction (ED), must be treated in a personalized way, taking into account co-morbidities such as ED, prostate hypertrophy, and lower urinary tract infections (IPB-LUTS). Diagnosing ED is also an opportunity for health because it can be a symptom of other very important diseases such as diabetes and cardiovascular diseases, and in particular ischemic heart disease. Despite the strong link with other diseases, ED is often undiagnosed.

The purpose of this Special Issue is to start from the actual incidence of ED in the world, to update all aspects of ED in multiple disciplines, and to explore the pathogenesis of ED, focusing on drug resistance and possible treatment options at the molecular level. The Special Issue is therefore dedicated to urologists, andrologists, cardiologists, diabetologists, and radiologists who wish to deepen their knowledge of this multidisciplinary pathology.

Dr. Giuseppe Massimo Sangiorgi
Guest Editor

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Keywords

  • erectile dysfunction
  • phosphodiesterase 5 inhibitors
  • endothelial dysfunction
  • stem cell
  • angioplasty
  • drug-eluting balloon

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Published Papers (2 papers)

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Research

15 pages, 1019 KiB  
Article
Rapamycin Suppresses Penile NADPH Oxidase Activity to Preserve Erectile Function in Mice Fed a Western Diet
by Justin D. La Favor, Clifford J. Pierre, Trinity J. Bivalacqua and Arthur L. Burnett
Biomedicines 2022, 10(1), 68; https://doi.org/10.3390/biomedicines10010068 - 30 Dec 2021
Cited by 3 | Viewed by 2489
Abstract
The mechanistic target of rapamycin (mTOR) is a nutrient-sensitive cellular signaling kinase that has been implicated in the excess production of reactive oxygen species (ROS). NADPH oxidase-derived ROS have been implicated in erectile dysfunction pathogenesis. The objective of this study was to determine [...] Read more.
The mechanistic target of rapamycin (mTOR) is a nutrient-sensitive cellular signaling kinase that has been implicated in the excess production of reactive oxygen species (ROS). NADPH oxidase-derived ROS have been implicated in erectile dysfunction pathogenesis. The objective of this study was to determine if mTOR is an activator of NADPH oxidase in the penis and to determine the functional relevance of this pathway in a translationally relevant model of diet-induced erectile dysfunction. Male mice were fed a control diet or a high-fat, high-sucrose Western style diet (WD) for 12 weeks and treated with vehicle or rapamycin for the final 4 weeks of the dietary intervention. Following the intervention, erectile function was assessed by cavernous nerve-stimulated intracavernous pressure measurement, in vivo ROS production was measured in the penis using a microdialysis approach, and relative protein contents from the corpus cavernosum were determined by Western blot. Erectile function was impaired in vehicle treated WD-mice and was preserved in rapamycin treated WD-mice. Penile NADPH oxidase-mediated ROS were elevated in WD-mice and suppressed by rapamycin treatment. Western blot analysis suggests mTOR activation with WD by increased active site phosphorylation of mTOR and p70S6K, and increased expression of NADPH oxidase subunits, all of which were suppressed by rapamycin. These data suggest that mTOR is an upstream mediator of NADPH oxidase in the corpus cavernosum in response to a chronic Western diet, which has an adverse effect on erectile function. Full article
(This article belongs to the Special Issue Erectile Dysfunction and Cardiovascular Disease)
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12 pages, 996 KiB  
Article
Efficacy of Penile Low-Intensity Shockwave Therapy and Determinants of Treatment Response in Taiwanese Patients with Erectile Dysfunction
by Kai-Yi Tzou, Su-Wei Hu, Oluwaseun Adebayo Bamodu, Yuan-Hung Wang, Wen-Ling Wu and Chia-Chang Wu
Biomedicines 2021, 9(11), 1670; https://doi.org/10.3390/biomedicines9111670 - 12 Nov 2021
Cited by 5 | Viewed by 2943
Abstract
Background: Erectile dysfunction (ED) remains an emotional wrench to patients and a therapeutic challenge to urologists in andrology clinics worldwide. This is, in part, related to refraction to, or transient effect of phosphodiesterase 5 inhibitors (PDE5i), coupled with patients’ dissatisfaction with this treatment [...] Read more.
Background: Erectile dysfunction (ED) remains an emotional wrench to patients and a therapeutic challenge to urologists in andrology clinics worldwide. This is, in part, related to refraction to, or transient effect of phosphodiesterase 5 inhibitors (PDE5i), coupled with patients’ dissatisfaction with this treatment modality. Low-intensity extracorporeal shockwave therapy (Li-ESWT) is an evolving treatment option, with promising curative potential. Current international guidelines are inconclusive, bear weak recommendation strength, and lack ethnogeographic consensus. Objectives: This study evaluated the safety, efficacy, and effect duration of Li-ESWT, as well as exploring disease-associated determinants of treatment success in Taiwanese males with ED. Methods: A cohort of 69 eligible cases treated with 12 sessions of Li-ESWT and followed up for at least 12 months after treatment, between January 2018 and December 2019 at our medical facility, was used. The present single-center, retrospective, non-randomized, single-arm study employed standardized erectile function evaluation indices, namely, the five-item International Index of Erectile Function (IIEF-5) and Erection Hardness Score (EHS). Clinicopathological analyses of selected variables and comparative analyses of time-phased changes in the EF indices relative to baseline values were performed. Evaluation of treatment success was based on minimal clinically important difference (MCID), using a binomial logistic regression model. Results: The median age and duration of ED for our Taiwanese cohort were 55 years and 12 months, respectively, and an average of 31.3% presented with co-morbidities. The mean improvement in IIEF-5, EHS, and quality of life (QoL) domain scores relative to the baseline values was statistically very significant (p < 0.001) at all indicated follow-up time-points. When stratified, Taiwanese patients with severe and moderate ED benefited more from Li-ESWT, compared with those in the mild or mild-to-moderate group. Patients’ pre-Li-ESWT PDE5i response status was not found to significantly influence Li-ESWT response. Univariate analysis showed that age > 45 years (p = 0.04), uncontrolled diabetes mellitus (p = 0.04), and uncontrolled hyperlipidemia (p = 0.01) were strongly associated with Li-ESWT efficacy; however, only age > 45 years (p = 0.04) and uncontrolled hyperlipidemia (p = 0.03) were found to be independent negative predictors of Li-ESWT success by the multivariate logistic model. Follow-up was uneventful, with no treatment-related adverse events or side effects reported. Of the treated patients, 86.1% indicated satisfaction with the treatment regimen, and over 90% indicated they would recommend the same therapy to others. Conclusions: Li-ESWT is a safe and efficacious therapeutic modality for Taiwanese patients with ED. Uncontrolled hyperlipidemia and age > 45 years are independent negative predictors of treatment success for this cohort. Full article
(This article belongs to the Special Issue Erectile Dysfunction and Cardiovascular Disease)
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