Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches 2.0
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 8148
Special Issue Editors
Interests: reactive oxygen species; vascular inflammation; endothelial dysfunction; biomaterials; tumor microenvironments
Special Issues, Collections and Topics in MDPI journals
2. Department of Physiology, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, Republic of Korea
Interests: aortic inflammation; vascular inflammation; endothelial activation
Special Issue Information
Dear Colleagues,
The Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches 2.0”, will focus on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions related to vascular inflammation.
Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. The chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment.
The pathophysiology of endothelial dysfunction (ED) is complex, and multifactorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions as well as the early detection or molecular imaging techniques for endothelial dysfunction help to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had a promising beneficial effect in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host–immune responses near tumor environments.
This Special Issue is open for a wide range of basic to preclinical research studies, or those adopting a multidisciplinary approach, and will also cover original articles and reviews on the following topics:
- Target molecules or pathophysiology
- Primary prevention of cardiovascular risk factors
- Early detection or molecular imaging techniques
- New therapeutic approaches including biomaterials development
- Drug delivery systems
- Immunology and tumor environments
Dr. Byeong Hwa Jeon
Dr. Hee Kyoung Joo
Guest Editors
Manuscript Submission Information
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Keywords
- endothelial dysfunction
- endothelial activation
- reactive oxygen species and lipid peroxidation
- atherosclerosis
- adipose tissues and obesity
- hypertension
- hypercholesterolemia
- vascular inflammation
- tumor microenvironment
- new biomarker or pathophysiology
- novel therapeutic approach and pharmaceuticals
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