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Anomalous Angiogenesis in Retina

Department of Mathematics, Gregorio Millán Institute, Fluid Dynamics, Nanoscience and Industrial Mathematics, Universidad Carlos III de Madrid, 28911 Leganés, Spain
Author to whom correspondence should be addressed.
Academic Editor: Nadia Alfaidy
Biomedicines 2021, 9(2), 224;
Received: 23 December 2020 / Revised: 9 February 2021 / Accepted: 14 February 2021 / Published: 22 February 2021
(This article belongs to the Special Issue Angiogenesis and Inflammation in Biological Barriers)
Age-related macular degeneration (AMD) may cause severe loss of vision or blindness, particularly in elderly people. Exudative AMD is characterized by the angiogenesis of blood vessels growing from underneath the macula, crossing the blood–retina barrier (which comprises Bruch’s membrane (BM) and the retinal pigmentation epithelium (RPE)), leaking blood and fluid into the retina and knocking off photoreceptors. Here, we simulate a computational model of angiogenesis from the choroid blood vessels via a cellular Potts model, as well as BM, RPE cells, drusen deposits and photoreceptors. Our results indicate that improving AMD may require fixing the impaired lateral adhesion between RPE cells and with BM, as well as diminishing Vessel Endothelial Growth Factor (VEGF) and Jagged proteins that affect the Notch signaling pathway. Our numerical simulations suggest that anti-VEGF and anti-Jagged therapies could temporarily halt exudative AMD while addressing impaired cellular adhesion, which could be more effective over a longer time-span. View Full-Text
Keywords: cellular potts model; exudative age-related macular degeneration; angiogenesis; notch signaling pathway; systems biology cellular potts model; exudative age-related macular degeneration; angiogenesis; notch signaling pathway; systems biology
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MDPI and ACS Style

Vega, R.; Carretero, M.; Bonilla, L.L. Anomalous Angiogenesis in Retina. Biomedicines 2021, 9, 224.

AMA Style

Vega R, Carretero M, Bonilla LL. Anomalous Angiogenesis in Retina. Biomedicines. 2021; 9(2):224.

Chicago/Turabian Style

Vega, Rocío, Manuel Carretero, and Luis L. Bonilla 2021. "Anomalous Angiogenesis in Retina" Biomedicines 9, no. 2: 224.

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