Vitamin D: Latest Scientific Discoveries in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 354

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Guest Editor
Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medial Science, Poznan, Poland
Interests: vitamin D; pharmacogenetics; pharmacokinetics; public health; epidemiology
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Special Issue Information

Dear Colleagues,

Vitamin D is widely recognized for its role in bone health and calcium regulation. Recent research shows that vitamin D’s molecular mechanisms also influence many pathophysiological processes in human diseases. Studies indicate that vitamin D may support immune responses, help prevent certain chronic disorders, and benefit overall well-being. As personalized medicine and preventive healthcare grow, new findings highlight vitamin D’s potential roles in immune function, cardiovascular health, metabolic pathways, and infection-related outcomes. Advances in research technology are further clarifying how vitamin D status affects cellular signaling, gene expression, and tissue-level pathology.

This Special Issue invites original research, reviews, meta-analyses, and expert opinions on vitamin D’s molecular, cellular, and pathological dimensions. We welcome submissions examining vitamin D’s mechanisms of action at the cellular and tissue levels, its roles in immune and cardiovascular systems, its metabolic and neurological functions, and its contributions to other organ-specific pathologies. We also encourage research on vitamin D deficiency patterns, as well as laboratory or clinical interventions grounded in disease-focused and translational studies.

By bringing together leading experts and new discoveries, we aim to deepen our understanding of vitamin D’s influence on pathogenesis, therapeutic strategies, and biomedical applications. We hope that these contributions will guide future investigations and inspire innovative collaborations in the field.

Dr. Mohamed Abouzid
Guest Editor

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Keywords

  • vitamin D
  • vitamin D metabolites
  • metabolic pathways
  • vitamin D receptor
  • polymorphisms
  • pathogenesis
  • vitamin D deficiency

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Published Papers (1 paper)

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Research

16 pages, 1075 KiB  
Article
Analysis of Vitamin D and VDR Expression in Women with Advanced Endometriosis: A Case–Control Study in Thailand
by Vitet Layanun, Woraluk Somboonporn, Pinya Aupongkaroon, Pilaiwan Kleebkaow, Nipon Chaisuriya and Naree Pluthikarmpae
Biomedicines 2025, 13(7), 1605; https://doi.org/10.3390/biomedicines13071605 - 30 Jun 2025
Viewed by 133
Abstract
Background: Vitamin D has anti-inflammatory and immunomodulatory properties that may influence the pathophysiology of endometriosis. This study investigated the association between vitamin D levels and endometriosis, and vitamin D receptor (VDR) expression in endometriotic tissue. Methods: A cross-sectional study was conducted involving 36 [...] Read more.
Background: Vitamin D has anti-inflammatory and immunomodulatory properties that may influence the pathophysiology of endometriosis. This study investigated the association between vitamin D levels and endometriosis, and vitamin D receptor (VDR) expression in endometriotic tissue. Methods: A cross-sectional study was conducted involving 36 patients with endometriosis and 72 healthy control women, matched for age and BMI. Serum 25-hydroxyvitamin D levels were measured and categorized into four statuses (normal, insufficiency, deficiency, and severe deficiency). Endometriotic tissue samples were examined for VDR expression using immunohistochemistry and qualitatively quantified using histo-scores (H-scores). Endometriosis severity was assessed using the revised criteria of the American Society for Reproductive Medicine (rASRM). Results: No statistically significant difference in vitamin D levels between the groups (20.45 vs. 21.10 ng/dL, p = 0.190) was observed, even after adjusting for residence, body sunscreen use, pregnancy, and contraceptive use. VDR expression exhibited significantly higher H-scores in endometriotic epithelial cells than in stromal cells (209.51 vs. 73.32; p < 0.001). Additionally, the VDR H-score in both cell compartments showed no significant difference according to vitamin D status. No statistically significant association was found between vitamin D levels, VDR expression, or disease severity. The odds of severe endometriosis were 2.17 (95% CI: 0.14–33.80) for vitamin D insufficiency and 4.33 (95% CI: 0.24–115.67) for deficiency compared with normal vitamin D. Conclusions: There was no statistically significant association between vitamin D levels and endometriosis and VDR. Full article
(This article belongs to the Special Issue Vitamin D: Latest Scientific Discoveries in Health and Disease)
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