Genetically Determined Cardiovascular Disease

Dear Colleagues,

Genetically determined cardiovascular diseases (CVDs) encompass a spectrum of disorders rooted in hereditary predispositions, including monogenic mutations and polygenic risk factors. These conditions, such as familial hypercholesterolemia, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy, often manifest early in life and confer elevated risks of myocardial infarction, sudden cardiac death, or heart failure. Advances in genomic sequencing have unveiled critical genetic variants (e.g., LDLR, MYH7, and PKP2) that disrupt lipid metabolism, myocardial contraction, or cardiac electrophysiology. Epigenetic modifiers and gene–environment interactions further modulate disease penetrance, underscoring the complexity of inherited CVD pathogenesis.

This Special Issue welcomes comprehensive reviews and original research articles that explore cutting-edge diagnostic and therapeutic strategies, including polygenic risk scoring, CRISPR-based gene editing, and targeted pharmacotherapies. Contributions may also address challenges in genetic counseling, the ethical implications of predictive testing, and the integration of multi-omics data to refine precision medicine approaches.

Dr. Gaetano Thiene
Guest Editor

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