Druggability of Proteins/Enzymes

Dear Colleagues,

This Special Issue will cover all aspects of research works on druggable proteins and enzymes.

The human genome encodes approximately 20,000 proteins, a handful of which are suitable for drug–protein interactions. Within this group, even fewer are effectively targeted by drugs. This subgroup is defined here as the druggable proteins/enzymes with a specific affinity to bind small molecule(s) or antibodies mediating a signal transduction network involved in disease control.

Suitable manuscripts include, but are not limited to, research and review manuscripts that address enzyme and protein activities targeted by drugs converting signal transduction from the site of interaction into specific responses inside the cell resulting, for example, in gene expression, cell division, and/or cell death.

Research works of antibody-based drugs that cannot pass the plasma membrane are also welcome as they are mostly directed against protein targets on the cell surface (receptors) affecting their activities.

Additional druggable proteins that are of interest include, but are not limited to, all works on transporters, G-protein coupled receptors, CD markers, nuclear receptors, voltage-gated ion channels, etc.

Dr. Ruth Vinall
Dr. Simeon Kotchoni
Guest Editors

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