The Conundrum of Poor Ovarian Response: From Diagnosis to Treatment

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 186

Special Issue Editor


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Guest Editor
1. Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens, Greece
2. Medical School, National and Kapodistrian University of Athens, Athens, Greece
Interests: infertility; assisted reproduction; reproductive endocrinology; poor ovarian response; ovarian stimulation; ovarian aging; pregnancy complications; minimally invasive surgery; hysteroscopy; endoscopy; colposcopy; evidence-based medicine
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Special Issue Information

Dear Colleagues,

Advances observed in the field of reproductive medicine during the last four decades have led to the development of highly efficient ovarian stimulation protocols, and the subsequent improvement in reproductive outcomes. However, there is a special category of women who fail to adequately respond to controlled ovarian stimulation, also known as “poor responders”. Numerous underlying mechanisms have been proposed for POR pathogenesis, from follicular insensitivity to exogenous gonadotrophins, down to even lifestyle parameters. Additionally, several associations and causative relationships regarding POR have been proposed, ranging from advanced maternal age and reduced ovarian reserve, to genetic or even iatrogenic factors. Despite the fact that POR has been investigated for almost three decades, there is still no consensus with regard to POR patient categorization and characterization, subsequently leading to discrepancies regarding POR management among clinicians worldwide.

Considering the significance of improving POR patient performance, we invite clinicians and reproductive scientists to contribute to this Special Issue with original research articles and comprehensive review papers, focusing on POR pathogenesis at molecular, genetic and epigenetic levels. In addition, studies focused on unveiling novel biomarkers as well as novel algorithms for accurately predicting an expected poor ovarian response are also invited. Finally, studies investigating novel treatments and protocols aiming to improve the ovarian response would be of added value.

We believe that a series of articles within this framework will make a valuable contribution towards better understanding and managing this multifactorial condition.

Dr. Theodoros Kalampokas
Guest Editor

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Keywords

  • assisted reproduction
  • in vitro fertilization (IVF)
  • poor ovarian response (POR)
  • ovarian functionality
  • ovarian aging
  • ovarian stimulation
  • adjuvant treatment
  • biomarkers

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