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Biomedicines
Special Issues
Emerging Trends in Reproductive Endocrinology and Pregnancy-Related Disorders
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Emerging Trends in Reproductive Endocrinology and Pregnancy-Related Disorders

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 846

Special Issue Editor

Dr. Theodoros Kalampokas

E-Mail Website
Guest Editor
Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, Greece
Interests: high-risk pregnancies; pregnancy-related disorders; obstetrics; reproductive endocrinology; minimally invasive surgery; evidence based medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Pregnancy-related disorders, such as preeclampsia, eclampsia, gestational diabetes, and the complex management of multiple pregnancies, continue to pose significant risks to maternal and neonatal health worldwide. This Special Issue aims to highlight the pressing need for advanced research in the field of reproductive endocrinology and obstetric pathophysiology. Emphasis is placed on the development and integration of innovative diagnostic and therapeutic strategies to enhance early detection and personalized management of these conditions. State-of-the-art molecular and imaging technologies—such as OMICs platforms (genomics, proteomics, metabolomics) and advanced imaging—are rapidly transforming the clinical landscape, offering promising avenues for improved outcomes.

A multidisciplinary approach involving obstetrics, endocrinology, molecular biology, medical genetics, and bioinformatics is essential to elucidate the complex etiologies and pathophysiological mechanisms underlying pregnancy-related disorders. Moreover, the incorporation of precision medicine and personalized therapeutic protocols, tailored to the genetic and biochemical profile of each patient, is becoming increasingly vital. The potential application of artificial intelligence and machine learning in optimizing clinical decision-making and predicting adverse maternal–fetal outcomes further underscores the necessity of integrating cutting-edge technology into maternal care.

We warmly welcome submissions from reproductive endocrinologists, maternal–fetal medicine specialists, molecular biologists and geneticists, pharmacologists, and researchers working in related fields to contribute their original research articles and reviews. We also encourage interdisciplinary collaborations that bridge basic science and clinical applications in pregnancy-related disorders and reproductive endocrinology.

Dr. Theodoros Kalampokas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy-related disorders
  • eclampsia
  • preeclampsia
  • hypertensive disorders of pregnancy
  • gestational diabetes
  • reproductive endocrinology
  • precision medicine

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Published Papers (1 paper)

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13 pages, 799 KB  
Article
Protein C Levels in Human Immunodeficiency Virus-Infected Women with and Without Pre-Eclampsia in South Africa
by Wendy N. Phoswa, Lawrence Chauke, Kabelo Mokgalaboni, Gaynor Balie, Sidney Hanser and Olive P. Khaliq
Biomedicines 2026, 14(4), 866; https://doi.org/10.3390/biomedicines14040866 - 10 Apr 2026
Viewed by 542
Abstract
Background: Pre-eclampsia (PE) is a significant cause of maternal and perinatal morbidity and mortality globally and is characterized by impaired endothelial function and disturbances in coagulation pathways. The effects of Human Immunodeficiency Virus (HIV) on the immune and coagulation systems have been investigated [...] Read more.
Background: Pre-eclampsia (PE) is a significant cause of maternal and perinatal morbidity and mortality globally and is characterized by impaired endothelial function and disturbances in coagulation pathways. The effects of Human Immunodeficiency Virus (HIV) on the immune and coagulation systems have been investigated during pregnancy, but there are few reports on anticoagulant factors in pregnant women who are infected with HIV and develop PE. This investigation compares plasma protein C levels in pregnant women with pre-eclampsia and those without pre-eclampsia, and compares the results based on their HIV status. Methods: A hospital-based cross-sectional study design was used for the current research, which was carried out at Charlotte Maxeke Johannesburg Academic Hospital, South Africa. A total of 83 pregnant women participated in the study and were categorized into one of four groups: normotensive HIV-negative (n = 36); normotensive HIV-positive (n = 18); pre-eclamptic HIV-negative (n = 21); and pre-eclamptic HIV-positive (n = 8). Data collected included demographic information and clinical characteristics that were abstracted from maternity records. Plasma protein C concentrations were determined by ELISA (enzyme-linked immunosorbent assay). Nonparametric statistical methods were used to compare the mean values of plasma protein C between each of the four groups, and significance was set at p < 0.05. Subgroup analyses, particularly for the pre-eclamptic HIV-positive group (n = 8), were considered exploratory due to small sample sizes. Results: As would be anticipated, both systolic and diastolic blood pressure values were significantly elevated in the pre-eclamptic group when compared to the normotensive control subjects (p < 0.0001). There were no statistically significant differences in plasma protein C concentration between the normotensive and pre-eclamptic groups, nor between the HIV-negative and HIV-positive groups. Similarly, there were no significant differences in plasma protein C concentration when comparing all four study groups (Kruskal–Wallis test p = 0.2295). Conclusions: Plasma protein C concentrations did not vary significantly according to the presence of pre-eclampsia or HIV status in this cohort. These findings suggest that protein C concentrations were not measurably altered between groups within this study population. However, due to the small sample size in key subgroups, these findings should be considered preliminary and interpreted with caution. Larger, adequately powered studies are required to further investigate potential associations between HIV infection, pre-eclampsia, and anticoagulant pathways during pregnancy. Full article
(This article belongs to the Special Issue Emerging Trends in Reproductive Endocrinology and Pregnancy-Related Disorders)
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