Molecular Mechanisms of Cancer Drug Resistance
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 12676
Special Issue Editors
Interests: breast cancer; colon cancer; drug-resistant; metronomic chemotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: cancer cell biology; mechanisms of cancer cell death; cancer stem cells; drug resistance; tumor microenvironment; microbiome and cancer; pharmacology; pharmacokinetics of antineoplastic drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug resistance, existing before treatment (intrinsic) or generated after therapy (acquired), is responsible for most cancer relapses and associated deaths. Drug resistance arises not only with classical chemotherapy but also, more recently, with tumor-target and immunotarget therapies.
The heterogeneity among patients, tumors, and cancer microenvironments and the adaptability of cancer cells in evading therapies make it more challenging to address drug resistance. Although our knowledge in understanding drug resistance over the past decade has definitively grown, gaps remain in identifying the biological, pharmacodynamic, and pharmacokinetic causes behind drug resistance and designing cancer therapies and schedules to overcome it.
This Special Issue aims to respond to this clinical need, with studies leading to the discovery of significant biomarkers for the development of a new combination of anticancer treatments that prevent or overcome potential resistance. Furthermore, emphasizing the pharmacological action of anticancer drugs may help to challenge complexity by better predicting optimal strategies.
Dr. Maria Grazia Cerrito
Prof. Dr. Guido Bocci
Guest Editors
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Keywords
- drug resistance
- intracellular signaling mechanisms
- cancer stem cells
- tumor microenvironment
- extracellular vesicles
- liquid biopsies
- drug repurposing
- immunotherapy
- pharmacology
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