Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease: 2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 29 April 2026 | Viewed by 1
Special Issue Editor
Interests: gastroenterology; gastrointestinal diseases; cancer; mucosal inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diseases of the gastrointestinal tract comprise a wide range of disorders affecting the digestive system and remain a major focus of biomedical research and clinical practice worldwide. Conditions such as inflammatory bowel disease, irritable bowel syndrome, gastroesophageal reflux, peptic ulcers, celiac disease, gastrointestinal motility disorders, liver disease, and gastrointestinal cancers involve complex and diverse cellular and molecular mechanisms. Comorbidities that exacerbate these conditions are also of particular interest.
Cellular targets are present in the epithelial barriers, mucosal tissues, accessory glands, the immune system, and the enteric nervous system, while key molecular pathways involve cytokines and chemokines in inflammation, fibrotic remodeling, dysregulated immune responses, genetic susceptibility, abnormalities in the gut–brain axis, visceral hypersensitivity, pathogens, mucosal disruption, cancer, smooth muscle abnormalities. Understanding these cellular and molecular mechanisms is crucial for developing targeted therapies, diagnostic tools, and interventions for the diverse array of gastrointestinal diseases resulting in precision medicine and personalized treatment approaches. Studies in this area involve the oral cavity, esophagus, stomach, small and large intestines, salivary glands, liver, pancreas, and gallbladder.
This Special Issue welcomes original research and reviews that deepen our understanding of the molecular and cellular basis of gastrointestinal diseases, including mechanistic insights, novel diagnostic approaches, and therapeutic innovations. Papers on other topics linked to gastrointestinal tract diseases not included here, however, will also be considered by the editorial team.
Dr. Felipe Leite De Oliveira
Guest Editor
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Keywords
- cellular mechanisms
- molecular mechanisms
- diagnosis
- treatment
- experimental models
- signaling pathways
- comorbidities
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