Antibacterial Applications of Bioactive Nanoparticles

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 2934

Special Issue Editors


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Guest Editor
Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam 13120, Gyeonggi‑do, Republic of Korea
Interests: biomaterials; bioactive nanoparticles and nanoconjugates; multidrug-resistant microorganisms
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Guest Editor
Department of Food Science and Biotechnology, Gachon University, Seongnam 461-701, Republic of Korea
Interests: antimicrobial agents; synthesis of biomaterials; food safety
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoparticles are small particles, with a size ranging 1 nm to 100 nm, and have attracted significant interest from scientists due to their multiple applications in diverse fields of science including biomedicine, pharmaceutics, agriculture, textile, food technology, and catalysis. There are different types of nanoparticles, such as silver, gold, cobalt, copper (II), iron, lithium, magnesium and zinc. The core features of these nanomaterials are their small size, with a large surface area, modification capability, polarity and property diversity. The application of these bioactive nanoparticles in the biomedical field offers many revolutionary solutions regarding the development of multi-functionalized drugs and products with antibacterial properties. Different methods, such as biological, physical, and chemical methods, have been applied to the facile and rapid synthesis of these bioactive nanoparticles. The emergence of multidrug-resistant bacteria is a major concern for public health. Antibiotic-resistant microorganisms cause life-threatening diseases in humans. The development of novel antibacterial agents is a key solution to this issue. Therefore, bioactive nanoparticles could be promising agents to control these multidrug-resistant bacteria. Various green methods could be used for the facile, rapid and mass production of nanoparticles. The synthesized nanoparticles could be utilized as antibacterial agents to control various pathogenic bacteria. This research topic will focus on the antibacterial applications of bioactive nanoparticles and is an open forum in which scientists/researchers may share their knowledge, investigations and findings in this promising field.

Dr. Md Amdadul Huq
Dr. Shahina Akter
Guest Editors

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Keywords

  • bioactive nanoparticles
  • green synthesis
  • antibacterial applications
  • antibacterial mechanisms
  • biofilm inhibition
  • multidrug-resistant bacteria

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Published Papers (1 paper)

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Research

20 pages, 9365 KiB  
Article
Role of Citrullus colocynthis and Psidium guajava Mediated Green Synthesized Silver Nanoparticles in Disease Resistance against Aeromonas hydrophila Challenge in Labeo rohita
by Ramsha Hafeez, Zakia Kanwal, Muhammad Akram Raza, Shafqat Rasool, Saira Riaz, Shahzad Naseem, Shifa Rabani, Imran Haider, Naushad Ahmad and Suliman Yousef Alomar
Biomedicines 2023, 11(9), 2349; https://doi.org/10.3390/biomedicines11092349 - 23 Aug 2023
Cited by 5 | Viewed by 2052
Abstract
Green synthesis of metallic nanoparticles is an auspicious method of preparing nanoparticles using plant extracts that have lesser toxicity to animal cells and the host. In the present work, we analyzed the antibacterial activity of Citrullus colocynthis and Psidium guajava-mediated silver nanoparticles [...] Read more.
Green synthesis of metallic nanoparticles is an auspicious method of preparing nanoparticles using plant extracts that have lesser toxicity to animal cells and the host. In the present work, we analyzed the antibacterial activity of Citrullus colocynthis and Psidium guajava-mediated silver nanoparticles (Cc-AgNPs and Pg-AgNPs, respectively) against Aeromonas hydrophila (A. hydrophila) in an in vivo assay employing Labeo rohita (L. rohita). L. rohita were divided into six groups for both Cc-AgNPs and Pg-AgNPs treatments separately: Control, A. hydrophila infected, A. hydrophila + Ampicillin, A. hydrophila + Cc/Pg-AgNPs (25 µg/L), A. hydrophila + Cc/Pg-AgNPs (50 µg/L), and A. hydrophila + Cc/Pg-AgNPs (75 µg/L). Changes in different bio-indicators such as hematological, histological, oxidative stress, and cytokine analysis were observed. Interestingly, the infected fish treated with both types of AgNPs (Cc-AgNPs and Pg-AgNPs) exhibited a higher survival rate than the untreated infected fish and demonstrated signs of recovery from the infection, providing a compelling indication of the positive impact of phytosynthesized AgNPs. Disruptions in hematological and histological parameters were found in the infected fish. Both Cc-AgNPs and Pg-AgNPs showed recovery on the hematological and histological parameters. Analysis of oxidative stress and cytokine markers also revealed provoking evidence of the positive impact of Cc-AgNPs and Pg-AgNPs treatment against disease progression in the infected fish. The major finding of the study was that the higher concentrations of the nanoparticles (50 µg/L in the case of Cc-AgNPs and 75 µg/L in the case of Pg-AgNPs) were more effective in fighting against disease. In conclusion, our work presents novel insights for the use of green-synthesized AgNPs as economic and innocuous antibacterial candidates in aquaculture. Full article
(This article belongs to the Special Issue Antibacterial Applications of Bioactive Nanoparticles)
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