Advances in Research on Spermatozoa and Male Infertility: From Molecular Mechanism to Therapeutic Perspectives
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 56
Special Issue Editors
Interests: fertility; in vitro 3D models; fertilization process; window of implantation
Interests: reproductive biology; gametogenesis; molecular mechanisms of infertility
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Male infertility represents a significant and growing challenge worldwide, with sperm dysfunction representing one of the leading causes. Understanding the molecular mechanisms of spermatozoa function and pathology is crucial to developing innovative diagnostic tools and therapeutic strategies addressing for male infertility. This Special Issue aims to highlight cutting-edge advances in molecular and translational research on spermatozoa and male infertility, bridging the gap between fundamental science and clinical applications. We welcome original research and review articles addressing (but not limited to) the following topics:
- Molecular mechanisms underlying sperm function and dysfunction;
- Genetic, epigenetic, and proteomic profiling in male infertility;
- Advances in sperm analysis and diagnostic biomarkers;
- Novel in vitro and 3D models for studying fertilization;
- Translational research on assisted reproductive technologies (ARTs);
- Emerging therapeutic strategies for addressing male infertility.
Dr. Francesca Paola Luongo
Dr. Alice Luddi
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- spermatozoa biology
- molecular mechanisms of spermatogenesis
- oxidative stress and sperm function
- therapeutic strategies for addressing male infertility
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