Immunomodulation and Development of Immunotherapies for Human Autoimmunity, Inflammation, Infection, Allergy, and Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2021
Special Issue Editors
Interests: immunology; immunology in type 1 diabetes; host-parasite interaction; immunomodulation by parasite; autoimmunity and inflammation; T cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In mammals, the immune system protects the host by responding to attacks from a broad range of pathogens such as bacteria, parasites, and viruses while avoiding misguided or irrational immune reactions that are deleterious to the host. Both protective and detrimental immune responses are primarily facilitated by T and B cells, which possess enormous diversity in antigen recognition, high antigen specificity, potent effector activity, and long-lasting immunologic memory. Because of this potency, serious damage to the host may ensue if aberrant immune responses, such as autoimmunity or allergy, are triggered. A major challenge in immunology and biomedicine is to determine how the unresponsiveness of the adaptive immune system to self-antigens is established and maintained, and how the quality and magnitude of adaptive immune responses to non-self-antigens are controlled to avoid damage to the host. Despite technological advances, treatments for many and inflammatory and autoimmune diseases, including type 1 diabetes and rheumatoid arthritis, primarily rely on broad-spectrum immunosuppressive agents. However, the associated immunosuppressive regimens result in severe side effects, and safer and more effective treatments are thus required. Hence, increasing efforts have focused on developing immunotherapies aimed at targeting the underlying disease process to modulate the immune system, maximize critical cell function, and induce and/or enhance T-reg cells and their function.
Dr. Nitin P. Amdare
Dr. Phaneendra K. Duddempudi
Guest Editors
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Keywords
- immunomodulation
- immunotherapies
- immune system
- human autoimmunity
- inflammation
- infection
- allergy
- cancer
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