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Biomedicines
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Biological Aspects of Drug Addiction 2.0
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Biological Aspects of Drug Addiction 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 10145

Special Issue Editors

Prof. Dr. Gabriel Rubio

E-Mail Website
Guest Editor
Hospital Universitario 12 de Octubre, Madrid, Spain
Interests: psychiatry; harm reduction; addiction psychiatry; addiction psychology; dual (psychiatry) diagnosis; mental illness
Dr. Laura Orio

E-Mail Website
Guest Editor
Department of Psychobiology and Behavioral Sciences Methods, Faculty of Psychology, Complutense University of Madrid (UCM), Madrid, Spain
Interests: psychopharmacology; drug of abuse; substance use disorders; neuroinflammation; neurotoxicity; alcohol; immune system; Wernicke's encephalopathy; Korsakoff syndrome; dual disorders; apolipoproteins; acylethanolamides; oleoylethanolamide; cognitive decline; behavior

Special Issue Information

Dear Colleagues,

Drug addiction represents an important socioeconomic and health burden worldwide. Unfortunately, there are still no effective treatments for addiction, which is a chronic and relapsing disorder. Addiction has been conceptualized as a neurobiological disease in which repeated drug use yields lasting and widespread neuroadaptations that affect the brain regions responsible for habit forming, emotional regulation and cognitive processes, including planning, reasoning, decision making, impulse control and memory. Nevertheless, biological aspects of drug addiction involve more than a "vulnerable" or a "drug-sculpted" brain. Alterations in physiological systems, such as the cardiovascular, neuroendocrine, neuroimmune and gastrointestinal systems, are common in individuals with substance use disorders and may also be associated with the severity of the addictive disorder and/or vulnerability to drug use. In fact, substance use disorder is frequently associated with comorbid psychiatric disorders (such as mood disorders, anxiety, eating disorders and other substance use disorders) or other comorbid medical diseases (such as cancer, liver diseases and pancreatitis).

This Special Issue will focus on the biological aspects of drug addiction in a broad sense, including genetics, biochemical, physiological, functional and structural correlates found in the brain and also peripheral body tissues and organs. Understanding the biological basis of drug addiction will provide valuable opportunities for its prevention, diagnosis and treatment, since biological variables may serve as both biomarkers and therapeutic targets for the disease. Manuscripts dealing with the biological basis of behavioral addictions (i.e., sex, gambling, exercise, social media) are also welcome.

Prof. Dr. Gabriel Rubio
Dr. Laura Orio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • addiction
  • brain
  • peripheral organs
  • biomarkers
  • therapeutics
  • comorbidity

Related Special Issue

Published Papers (4 papers)

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Research

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20 pages, 4799 KiB  
Article
Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS
by María Rodríguez-Zapata, Milagros Galán-Llario, Héctor Cañeque-Rufo, Julio Sevillano, María Gracia Sánchez-Alonso, José M. Zapico, Marcel Ferrer-Alcón, María Uribarri, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Gonzalo Herradón, Carmen Pérez-García and Esther Gramage
Biomedicines 2023, 11(5), 1318; https://doi.org/10.3390/biomedicines11051318 - 28 Apr 2023
Cited by 1 | Viewed by 1678
Abstract
Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. PTN and MY10, an RPTPβ/ζ pharmacological inhibitor, modulate ethanol behavioral and microglial [...] Read more.
Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. PTN and MY10, an RPTPβ/ζ pharmacological inhibitor, modulate ethanol behavioral and microglial responses in adult mice. Now, to study the contribution of endogenous PTN and the implication of its receptor RPTPβ/ζ in the neuroinflammatory response in the prefrontal cortex (PFC) after acute ethanol exposure in adolescence, we used MY10 (60 mg/kg) treatment and mice with transgenic PTN overexpression in the brain. Cytokine levels by X-MAP technology and gene expression of neuroinflammatory markers were determined 18 h after ethanol administration (6 g/kg) and compared with determinations performed 18 h after LPS administration (5 g/kg). Our data indicate that Ccl2, Il6, and Tnfa play important roles as mediators of PTN modulatory actions on the effects of ethanol in the adolescent PFC. The data suggest PTN and RPTPβ/ζ as targets to differentially modulate neuroinflammation in different contexts. In this regard, we identified for the first time important sex differences that affect the ability of the PTN/RPTPβ/ζ signaling pathway to modulate ethanol and LPS actions in the adolescent mouse brain. Full article
(This article belongs to the Special Issue Biological Aspects of Drug Addiction 2.0)
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22 pages, 10830 KiB  
Article
Vicarious Social Defeat Increases Conditioned Rewarding Effects of Cocaine and Ethanol Intake in Female Mice
by Francisco Ródenas-González, María Carmen Arenas, María Carmen Blanco-Gandía, Carmen Manzanedo and Marta Rodríguez-Arias
Biomedicines 2023, 11(2), 502; https://doi.org/10.3390/biomedicines11020502 - 9 Feb 2023
Cited by 5 | Viewed by 1787
Abstract
Stress is a critical factor in the development of mood and drug use disorders. The social defeat model is not appropriate for female rodents due to their low level of aggression. Therefore, a robust female model of social stress needs to be developed [...] Read more.
Stress is a critical factor in the development of mood and drug use disorders. The social defeat model is not appropriate for female rodents due to their low level of aggression. Therefore, a robust female model of social stress needs to be developed and validated. The aim of the present study was to unravel the long-lasting effects of vicarious social defeat (VSD) on the conditioned rewarding effects of cocaine and ethanol intake in female mice. Although VSD seems to be a good model for inducing behavioral and physiologic endophenotypes induced by stress, there are no studies to date that characterize the effect of VSD on cocaine or alcohol use. The results confirm that VSD females showed an increase in corticosterone levels after a vicarious experience while also displaying an increase in anxiety- and anhedonic-like behaviors. Three weeks after the last VSD, vicariously defeated female mice showed an increased developed preference for a non-effective dose of cocaine in the conditioned place preference (CPP) paradigm and showed an increase in ethanol intake. Our results suggest that female mice vicariously experience a state of distress through the social observation of others suffering from adverse events, confirming the use of VSD as a valid model to study the response to social stress in females. The fact that VSD in females induced a comparable behavioral phenotype to that observed in physically defeated males could indicate a relationship with the higher rate of psychopathologies observed in women. Notwithstanding, more studies are needed to dissect the neurobiological and behavioral peculiarities of the female response to social stress. Full article
(This article belongs to the Special Issue Biological Aspects of Drug Addiction 2.0)
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Review

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55 pages, 1378 KiB  
Review
Cognitive Alterations in Addictive Disorders: A Translational Approach
by Ani Gasparyan, Daniel Maldonado Sanchez, Francisco Navarrete, Ana Sion, Daniela Navarro, María Salud García-Gutiérrez, Gabriel Rubio Valladolid, Rosa Jurado Barba and Jorge Manzanares
Biomedicines 2023, 11(7), 1796; https://doi.org/10.3390/biomedicines11071796 - 23 Jun 2023
Cited by 1 | Viewed by 2394
Abstract
The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be [...] Read more.
The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the end of drug abuse consumption. Improving our understanding of the molecular and cellular alterations associated with cognitive decline could be essential to developing specific therapeutic strategies for its treatment. Developing animal models to simulate drug abuse-induced learning and memory alterations is critical to continue exploring this clinical situation. The main aim of this review is to summarize the most recent evidence on cognitive impairment and the associated biological markers in patients addicted to some of the most consumed drugs of abuse and in animal models simulating this clinical situation. The available information suggests the need to develop more studies to further explore the molecular alterations associated with cognitive impairment, with the ultimate goal of developing new potential therapeutic strategies. Full article
(This article belongs to the Special Issue Biological Aspects of Drug Addiction 2.0)
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33 pages, 1040 KiB  
Review
The Inflammatory Signals Associated with Psychosis: Impact of Comorbid Drug Abuse
by Jesús Herrera-Imbroda, María Flores-López, Paloma Ruiz-Sastre, Carlos Gómez-Sánchez-Lafuente, Antonio Bordallo-Aragón, Fernando Rodríguez de Fonseca and Fermín Mayoral-Cleríes
Biomedicines 2023, 11(2), 454; https://doi.org/10.3390/biomedicines11020454 - 4 Feb 2023
Cited by 3 | Viewed by 3736
Abstract
Psychosis and substance use disorders are two diagnostic categories whose association has been studied for decades. In addition, both psychosis spectrum disorders and drug abuse have recently been linked to multiple pro-inflammatory changes in the central nervous system. We have carried out a [...] Read more.
Psychosis and substance use disorders are two diagnostic categories whose association has been studied for decades. In addition, both psychosis spectrum disorders and drug abuse have recently been linked to multiple pro-inflammatory changes in the central nervous system. We have carried out a narrative review of the literature through a holistic approach. We used PubMed as our search engine. We included in the review all relevant studies looking at pro-inflammatory changes in psychotic disorders and substance use disorders. We found that there are multiple studies that relate various pro-inflammatory lipids and proteins with psychosis and substance use disorders, with an overlap between the two. The main findings involve inflammatory mediators such as cytokines, chemokines, endocannabinoids, eicosanoids, lysophospholipds and/or bacterial products. Many of these findings are present in different phases of psychosis and in substance use disorders such as cannabis, cocaine, methamphetamines, alcohol and nicotine. Psychosis and substance use disorders may have a common origin in an abnormal neurodevelopment caused, among other factors, by a neuroinflammatory process. A possible convergent pathway is that which interrelates the transcriptional factors NFκB and PPARγ. This may have future clinical implications. Full article
(This article belongs to the Special Issue Biological Aspects of Drug Addiction 2.0)
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