Neuropathic Diseases: From Mechanisms to Novel Therapeutic Approaches

Dear Colleagues,

Neuropathic pain is caused by lesions or degeneration of the somatosensory system and is a major public health issue in the world. It is characterized by increased responses to nociceptive stimuli (hyperalgesia), unpleasant and abnormal sensations (dysesthesia), and pain in response to non-noxious tactile stimuli (allodynia). Several reports show that neuropathic pain raises a series of pathophysiologic events when the nervous tissue is damaged, including neuronal hyperexcitability, and neurogenic inflammation. Although the treatment for neuropathic pain remains a great challenge, progress has been made in identifying key molecules and their roles in pain modulation and processing. Thus, the identification of novel molecular and cellular targets for the development of effective and safe therapeutic strategies requires particular attention from the medical community.

In this Special Issue, original research articles and reviews are welcome. The purpose of this issue is to advance our understanding of novel neuropathic pain-related molecules and signaling pathways that can be used as therapeutic targets for the treatment of pain. Research areas may include (but not limited to) the following:

• Identification of potential therapeutic targets and pathophysiological mechanisms of neuropathic pain;
• Novel molecules, which are implicated in the pathophysiological changes in somatosensory system.

Dr. Yu-Cheng Ho
Dr. Ming Tatt Lee
Guest Editors

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